5-甲酰基-2-甲基吡啶合成路线 （共 22 条）
反应条件
β-VO(PO3)2 in gas T=400°C; selectivity of reaction, rates of partial and total oxidation; Product distributionRate constant;
参考文献
Chemistry of Heterocyclic Compounds (New York, NY, United States), , vol. 22, # 1 p. 63 - 66
Khimiya Geterotsiklicheskikh Soedinenii, , vol. 22, # 1 p. 75 - 79
反应条件
1: Methyltriphenylphosphonium bromide With n-butyllithium in tetrahydrofuran; hexane T=-78 - 20°C; 2: 6-Methyl-3-pyridine-carboxaldehyde in tetrahydrofuran; hexane T=0 - 20°C;
参考文献
RENOVIS, INC.
Patent: WO2009/110985 A2, 2009 ;
Location in patent: Page/Page column 63 ;
WO 2009/110985 A2
反应条件
1: 46.5 g / isopropyl acetate / 60 °C 2: 46.5 g / isopropyl acetate / 60 - 65 °C 3: t-BuOK / propan-2-ol; tetrahydrofuran / 0.5 h / 25 °C 4: 24.91 g / aq. HCl / 25 - 45 °C View Scheme
参考文献
Davies; Marcoux; Corley; Journet; Cai; Palucki; Wu; Larsen; Rossen; Pye; DiMichele; Dormer; Reider
Journal of Organic Chemistry, 2000 , vol. 65, # 25 p. 8415 - 8420
反应条件
1: 46.5 g / isopropyl acetate / 60 °C 2: 46.5 g / isopropyl acetate / 60 - 65 °C 3: t-BuOK / propan-2-ol; tetrahydrofuran / 0.5 h / 25 °C 4: 24.91 g / aq. HCl / 25 - 45 °C 5: t-BuOK / tetrahydrofuran / 0.75 h / 20 °C 6: AcOH; TFA / tetrahydrofuran / 0.75 h / 25 - 30 °C 7: 8.42 g / aq. NH4OH / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Davies; Marcoux; Corley; Journet; Cai; Palucki; Wu; Larsen; Rossen; Pye; DiMichele; Dormer; Reider
Journal of Organic Chemistry, 2000 , vol. 65, # 25 p. 8415 - 8420
反应条件
malonic acid; piperidine in pyridine
参考文献
Smith Kline and French Laboratories Limited
Patent: US4305945 A1, 1981 ;
US 4305945 A
反应条件
1: pyridine, piperidine
2: conc. H2SO4
3: H2 / 5percent Pd/C / ethanol / 45 °C
View Scheme
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
反应条件
1: pyridine, piperidine
2: conc. H2SO4
3: H2 / 5percent Pd/C / ethanol / 45 °C
4: sodium wire / diethyl ether / 18 h / Ambient temperature
5: ethanol / 7 h / Heating
6: 59 percent / NaOH / H2O; ethanol / 60 °C
View Scheme
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
反应条件
1: pyridine, piperidine
2: conc. H2SO4
View Scheme
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
反应条件
1: pyridine, piperidine
2: conc. H2SO4
3: H2 / 5percent Pd/C / ethanol / 45 °C
4: NaH / 1,2-dimethoxy-ethane / 20 h / Ambient temperature
View Scheme
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
反应条件
1: pyridine, piperidine
2: conc. H2SO4
3: H2 / 5percent Pd/C / ethanol / 45 °C
4: NaH / 1,2-dimethoxy-ethane / 20 h / Ambient temperature
5: sodium methoxide / methanol / 18 h / Heating
View Scheme
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
