1: 60 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C 3: TFA / tetrahydrofuran; H2O / 6 h / Ambient temperature 4: Pb(OAc)4, Na2CO3 5: 30 percent / benzene / 16 h / 80 °C 6: 80 percent / NaBH4, CeCl3 / propan-2-ol / 0 °C 7: 40 percent / 1) CBr4; / 2) CH3CN 8: LiHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C 9: -78 - -45 °C 10: 80 percent / (nBu)4NF / tetrahydrofuran / 0 - 25 °C 11: 70 percent / LiOH / 1,2-dimethoxy-ethane; H2O / Ambient temperature View Scheme

1: 60 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C 2: 80 percent / LiAlH4 / tetrahydrofuran / Heating 3: TFA / tetrahydrofuran; H2O / 16 h / Ambient temperature 5: 50 percent / benzene / 6 h / 80 °C 6: 80 percent / DMAP, Et3N / CH2Cl2 7: 90 percent / NaH / toluene 8: 90 percent / AlH3 / tetrahydrofuran / 0 °C 9: 60 percent / 1.) CBr4 2.) CH3CN 10: 30 percent / LiHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide 11: 70 percent / (nBu)4NF / tetrahydrofuran / 0 - 25 °C 12: 70 percent / K2CO3 / methanol; H2O View Scheme

1: lithium hexamethyldisilazane (LiHMDS) / tetrahydrofuran; hexamethylphosphoric acid triamide / 2.5 h / -78 - 20 °C 2: NaHCO3 / tetrahydrofuran; hexamethylphosphoric acid triamide / 2 h / Ambient temperature 3: 68 percent / AlH3*Et2O / tetrahydrofuran / 0.5 h / 0 °C 4: 85 percent / Et3N / CH2Cl2 / 0 °C 5: aq. TFA / tetrahydrofuran / Ambient temperature 6: Na2CO3, Pb(OAc)4 / CH2Cl2 / 0.25 h / -78 °C 7: toluene / 3 h / 80 °C 8: lithium hexamethyldisilazane (LiHMDS) / tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h / -78 - 0 °C 9: NaHCO3 / tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h / Ambient temperature 10: tetra-n-butylammonium fluoride / tetrahydrofuran / Ambient temperature 11: LiOH / 1,2-dimethoxy-ethane; H2O / Ambient temperature View Scheme