反应条件
1: 80 percent / KMnO4, 1 N H2SO4 / acetone; H2O / 1 h / pH=8.0 - 8.1
2: 66 percent / AlCl3 / 1,2-dichloro-ethane / 20 h / 25 °C
3: 34 percent / Et3N / dimethylformamide / 3 h / 40 - 50 °C
View Scheme
参考文献
Woltersdorf, O. W.; Schwam, H.; Bicking, J. B.; Brown, S. L.; deSolms, S. J.; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 11 p. 2486 - 2492