4,6-二氯-5-嘧啶甲醛合成路线 （共 55 条）
反应条件
in acetonitrile
T=200°C; 0.0166667 h; Microwave irradiation;
参考文献
Morrill, Christie; Babu, Suresh; Almstead, Neilg.; Moon, Young-Choon
Synthesis (Germany), 2013 , vol. 45, # 13 art. no. SS-2013-C0248-OP, p. 1791 - 1806
反应条件
triethylamine in tetrahydrofuran
T=20 - 65°C; 1 h;
参考文献
Boyd, Scott; Campbell, Leonie; Liao, Wensheng; Meng, Qinghong; Peng, Zuozhong; Wang, Xiaoping; Waring, Michael J.
Tetrahedron Letters, 2008 , vol. 49, # 52 p. 7395 - 7397
反应条件
triethylamine in tetrahydrofuran
T=65°C; 1 h;
参考文献
Morrill, Christie; Babu, Suresh; Almstead, Neilg.; Moon, Young-Choon
Synthesis (Germany), 2013 , vol. 45, # 13 art. no. SS-2013-C0248-OP, p. 1791 - 1806
反应条件
1: triethylamine / acetonitrile / 1 h / -15 °C / Inert atmosphere
2: hydroxylamine-o-sulphonic acid / acetonitrile / 16 h / 20 °C / Inert atmosphere; Molecular sieve
3: sodium hydroxide / dichloromethane; water / 6 h / Inert atmosphere
View Scheme
参考文献
Morrill, Christie; Babu, Suresh; Almstead, Neilg.; Moon, Young-Choon
Synthesis (Germany), 2013 , vol. 45, # 13 art. no. SS-2013-C0248-OP, p. 1791 - 1806
反应条件
in tetrahydrofuran
T=65°C; 1 h; Reagent/catalyst;
参考文献
Babu, Suresh; Morrill, Christie; Almstead, Neil G.; Moon, Young-Choon
Organic Letters, 2013 , vol. 15, # 8 p. 1882 - 1885
反应条件
1: N,N-dimethyl-formamide / 1 h / 20 °C / |Inert atmosphere
2: triethylamine / acetonitrile / 24 h / 65 °C / |Inert atmosphere
View Scheme
参考文献
Morrill, Christie; Babu, Suresh; Almstead, Neilg.; Moon, Young-Choon
Synthesis (Germany), 2013 , vol. 45, # 13 art. no. SS-2013-C0248-OP, p. 1791 - 1806
反应条件
in acetonitrile
T=200°C; 0.0833333 h; Microwave irradiation; TimeConcentration;
参考文献
Morrill, Christie; Babu, Suresh; Almstead, Neilg.; Moon, Young-Choon
Synthesis (Germany), 2013 , vol. 45, # 13 art. no. SS-2013-C0248-OP, p. 1791 - 1806
反应条件
hydroxylamine hydrochloride; sodium acetate in water; ethyl acetate
2 h;
参考文献
ARENA PHARMACEUTICALS INC.
Patent: WO2004/65380 A1, 2004 ;
Location in patent: Page 151-152 ;
WO 2004/065380 A1
反应条件
1: triethylamine / acetonitrile / 16 h / 0 °C / Inert atmosphere
2: hydroxylamine-o-sulphonic acid / acetonitrile / 16 h / 20 °C / Inert atmosphere; Molecular sieve
3: sodium hydroxide / dichloromethane; water / 6 h / Inert atmosphere
View Scheme
参考文献
Evans, Lindsay E.; Cheeseman, Matthew D.; Jones, Keith
Organic Letters, 2012 , vol. 14, # 13 p. 3546 - 3549
反应条件
1: N,N-dimethyl-formamide / 1 h / 20 °C / |Inert atmosphere
2: 1,4-dioxane / 0.33 h / 200 °C / |Sealed tube
View Scheme
参考文献
Morrill, Christie; Babu, Suresh; Almstead, Neilg.; Moon, Young-Choon
Synthesis (Germany), 2013 , vol. 45, # 13 art. no. SS-2013-C0248-OP, p. 1791 - 1806
