4,6-二氯嘧啶-5-甲腈合成路线 (共 6 条)
反应条件
thionyl chloride T=0 - 20°C; 3.5 h;
参考文献
ARENA PHARMACEUTICALS INC.
Patent: WO2004/65380 A1, 2004 ;
Location in patent: Page 151-152 ;
WO 2004/065380 A1
反应条件
thionyl chloride T=0 - 20°C; 3 h;
参考文献
ARENA PHARMACEUTICALS, INC.
Patent: WO2005/7647 A1, 2005 ;
Location in patent: Page/Page column 164 ;
WO 2005/007647 A1
反应条件
thionyl chloride T=0°C; 3 h; Heating / reflux;
参考文献
WO2006/118749 A1, ;
Page/Page column 88 ;
WO 2006/118749 A1
反应条件
1: With triethylamine; trichlorophosphate 3 h; Heating / reflux; 2: With sodium hydroxide in water
参考文献
US2007/72864 A1, ;
Page/Page column 33; 21 ;
US 20070072864 A1
反应条件
1: hydroxylamine hydrochloride; acetic acid / ethanol / 15 h / 20 °C 2: selenium(IV) oxide / toluene / 3 h / Reflux View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 9, # 5 p. 1516 - 1522
反应条件
ammonia in 1,4-dioxane; methanol T=0°C; 0.833333 h;
参考文献
ALMIRALL, S.A.; ERRA SOLA, Montserrat; CARRASCAL RIERA, Marta; TALTAVULL MOLL, Joan; CATURLA JAVALOYES, Juan Francisco; BERNAL ANCHUELA, Francisco Javier; PAGES SANTACANA, Lluis Miquel; MIR CEPEDA, Marta; CASALS COLL, Gaspar; HERNANDEZ OLASAGARRE, Maria Begoña
Patent: WO2014/60432 A1, 2014 ;
Location in patent: Page/Page column 159 ;