5,6-二氢-4H-环戊并噻唑-2-胺合成路线 （共 10 条）
反应条件
sodium hydrogencarbonate in tetrahydrofuran; water; ethyl acetate T=20°C; 0.25 h;
参考文献
Wyeth
Patent: US2007/149499 A1, 2007 ;
Location in patent: Page/Page column 19 ;
参考文献
LI, Wei; Li, Jianchang; Wu, Yuchuan; Wu, Junjun; Hotchandani, Rajeev; Tam, Steve Yikkai; Suhayl, Tarek; Sypek, Joseph P.; McFadyen, Iain
Patent: US2010/227859 A1, 2010 ;
Location in patent: Page/Page column 86-87 ;
US 20100227859 A1
参考文献
Chemische Berichte, , vol. 93, p. 1518 - 1525
Helvetica Chimica Acta, , vol. 24, p. 172 E, 175 E
反应条件
1: With sulfur in ethanol T=20°C; 2: With diethylamine in ethanol T=40°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 18 p. 5417 - 5422
反应条件
iodine T=100°C; 8 h;
参考文献
Ueda, Shigeo; Terauchi, Hideo; Kawasaki, Motoji; Yano, Akihiro; Ido, Motoharu
Chemical and Pharmaceutical Bulletin, 2004 , vol. 52, # 5 p. 634 - 637
反应条件
1: N-bromosuccinmide; ammonium acetate / diethyl ether / 0.5 h / 20 °C 2: triethylamine / ethanol / 2 h / Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 18 p. 5417 - 5422
反应条件
triethylamine in ethanol Hantzsch type reaction; 2 h; Reflux;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 18 p. 5417 - 5422
反应条件
copper(I) bromide; isopentyl nitrite in acetonitrile T=20°C; 4 h;
参考文献
LI, Wei; Li, Jianchang; Wu, Yuchuan; Wu, Junjun; Hotchandani, Rajeev; Tam, Steve Yikkai; Suhayl, Tarek; Sypek, Joseph P.; McFadyen, Iain
Patent: US2010/227859 A1, 2010 ;
Location in patent: Page/Page column 87 ;
US 20100227859 A1
反应条件
sodium hydrogencarbonate in isopropyl alcohol
T=0 - 40°C; 24.5 h;
参考文献
Wyeth
Patent: US2007/149499 A1, 2007 ;
Location in patent: Page/Page column 9-10; 18 ;
反应条件
1: 3.0 g / NaOEt; EtOH / 48 h / Heating
2: 62 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
3: 45 percent / MnO2 / CHCl3; methanol / 24 h / Heating
View Scheme
参考文献
Venkatesan, Aranapakam M.; Gu, Yansong; Santos, Osvaldo Dos; Abe, Takao; Agarwal, Atul; Yang, Youjun; Petersen, Peter J.; Weiss, William J.; Mansour, Tarek S.; Nukaga, Michiyoshi; Hujer, Andrea M.; Bonomo, Robert A.; Knox, James R.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 26 p. 6556 - 6568
