N(5)-[(E)-氨基(羟基亚胺)甲基]-L-鸟氨酸合成路线 （共 7 条）
反应条件
mammalian nitric oxide synthase; oxygen Enzyme kinetics;
参考文献
Huang; Hah; Silverman
Journal of the American Chemical Society, 2001 , vol. 123, # 11 p. 2674 - 2676
反应条件
1: 71.5 percent / HClO4 / 48 h
2: 93.7 percent / CH2Cl2 / 1.) 0 deg C, 1 h, 2.) RT, 3 h
3: 96 percent / H2 / Pd/C
4: 83 percent
5: NH2OH / dioxane / 1 h / Heating
6: 28 percent / trifluoroacetic acid
View Scheme
参考文献
Wallace; Fukuto
Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1746 - 1748
反应条件
1: 93.7 percent / CH2Cl2 / 1.) 0 deg C, 1 h, 2.) RT, 3 h
2: 96 percent / H2 / Pd/C
3: 83 percent
4: NH2OH / dioxane / 1 h / Heating
5: 28 percent / trifluoroacetic acid
View Scheme
参考文献
Wallace; Fukuto
Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1746 - 1748
反应条件
1: 96 percent / H2 / Pd/C
2: 83 percent
3: NH2OH / dioxane / 1 h / Heating
4: 28 percent / trifluoroacetic acid
View Scheme
参考文献
Wallace; Fukuto
Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1746 - 1748
反应条件
1: NH2OH / dioxane / 1 h / Heating
2: 28 percent / trifluoroacetic acid
View Scheme
参考文献
Wallace; Fukuto
Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1746 - 1748
反应条件
1: 83 percent
2: NH2OH / dioxane / 1 h / Heating
3: 28 percent / trifluoroacetic acid
View Scheme
参考文献
Wallace; Fukuto
Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1746 - 1748
反应条件
trifluoroacetic acid
参考文献
Wallace; Fukuto
Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1746 - 1748
