3-甲氧基-2-硝基苯甲醛合成路线 （共 29 条）
反应条件
1: BBr3 / CH2Cl2
2: K2CO3 / dimethylsulfoxide
View Scheme
参考文献
Verma, Kirti Dhingra; Forgacs, Attila; Uh, Hyounsoo; Beyerlein, Michael; Maier, Martin E.; Petoud, Stephane; Botta, Mauro; Logothetis, Nikos K.
Chemistry - A European Journal, 2013 , vol. 19, # 52 p. 18011 - 18026
反应条件
1: BBr3 / CH2Cl2
2: K2CO3 / dimethylsulfoxide
3: NaBH4 / ethanol; methanol
View Scheme
参考文献
Verma, Kirti Dhingra; Forgacs, Attila; Uh, Hyounsoo; Beyerlein, Michael; Maier, Martin E.; Petoud, Stephane; Botta, Mauro; Logothetis, Nikos K.
Chemistry - A European Journal, 2013 , vol. 19, # 52 p. 18011 - 18026
反应条件
1: dichloromethane / 8 h / 20 °C / |Inert atmosphere
2: acetic acid; iron / ethanol / 0.08 h / 20 °C / |Reflux
3: potassium carbonate; 1,4-diaza-bicyclo[2.2.2]octane; copper(l) iodide / 1,4-dioxane / 4 h / |Schlenk technique; |Inert atmosphere; |Reflux
View Scheme
参考文献
Xiao, Xiong; Chen, Tian-Qi; Ren, Jiangmeng; Chen, Wei-Dong; Zeng, Bu-Bing
Tetrahedron Letters, 2014 , vol. 55, # 13 p. 2056 - 2060
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide)
T=60°C;
参考文献
Boehringer Ingelheim Pharmaceuticals, Inc.
Patent: US2004/186114 A1, 2004 ;
Location in patent: Page/Page column 68 ;
反应条件
boron tribromide in dichloromethane
参考文献
Nippon Shinyaku Co., Ltd.
Patent: EP1382335 A1, 2004 ;
Location in patent: Page/Page column 7 ;
反应条件
1: sodium azide / N,N,N',N',N'',N''-hexamethylphosphoric triamide / 0 - 20 °C / Inert atmosphere
2: water; sodium hydroxide / ethanol / 20 °C / Inert atmosphere
3: pyridine; acetic anhydride / 20 °C / Inert atmosphere
4: Rh2(esp)2 / toluene / 0.5 h / 75 °C / Inert atmosphere; Molecular sieve; Sealed tube
View Scheme
参考文献
Stokes, Benjamin J.; Liu, Sheng; Driver, Tom G.
Journal of the American Chemical Society, 2011 , vol. 133, # 13 p. 4702 - 4705
反应条件
1: n-BuLi / tetrahydrofuran
2: H2 / 10percent Pd/C / ethyl acetate / 1 h / 760 Torr
View Scheme
参考文献
Kimura; Watanabe; Matsui; Hayashi; Tanaka; Ohtsuka; Saeki; Kogushi; Kabayashi; Akasaka; Yamagishi; Saitou; Yamatsu
Journal of Medicinal Chemistry, 1993 , vol. 36, # 11 p. 1641 - 1653
反应条件
1: 96 percent / potassium fluoride; 18-crown-6 / propan-2-ol / 16 h / 20 °C
2: 96 percent / acetic anhydride; sodium acetate; 18-crown-6 / potassium fluoride / 64 h / 20 °C
3: 62 percent / hydrogen / 10 percent Pd/C / ethyl acetate; acetic acid; ethanol / 3 h
View Scheme
参考文献
Chen, Bang-Chi; Hynes Jr., John; Pandit, Chennagiri R.; Zhao, Rulin; Skoumbourdis, Amanda P.; Wu, Hong; Sundeen, Joseph E.; Leftheris, Katerina
Heterocycles, 2001 , vol. 55, # 5 p. 951 - 960
反应条件
1: hydrogenchloride; iron / ethanol; water / 2 h / Reflux
2: potassium hydroxide / ethanol / 15 h / Reflux
3: hydrogen bromide / water / 16 h / 120 °C
View Scheme
参考文献
El Ojaimi, Maya; Thummel, Randolph P.
Inorganic Chemistry, 2011 , vol. 50, # 21 p. 10966 - 10973
