11a-羟基-18-甲基雌甾-4-烯-3,17-二酮合成路线 （共 4 条）
反应条件
1: 94 percent / Jones' reagent / acetone / 0.25 h / -15 - -10 °C 2: 79 percent / HC(OEt)3, p-TsOH*H2O / CH2Cl2 / 7 h / Heating 3: 88 percent / benzene; diethyl ether / 3 h / 10 - 15 °C 4: 74 percent / p-TsOH*H2O / formic acid / 7 h / 50 - 60 °C 5: 98 percent / BF3*Et2O / methanol / 2.5 h / 0 - 5 °C 6: 100 percent / NaBH4 / methanol / 2 h / Ambient temperature 7: 94 percent / Na, liq. NH3 / tetrahydrofuran / 0.5 h / -50 - -45 °C 8: 82 percent / Jones' reagent / acetone / 0.25 h / -15 - -10 °C 9: 72 percent / n-C4H9Br, Li / tetrahydrofuran; diethyl ether / 1.) -10 deg C, 2 h; -5 deg C, 3 h, 2.) -5 deg C, 3 h View Scheme
参考文献
Organic Preparations and Procedures International, , vol. 29, # 5 p. 572 - 576
反应条件
1: 94 percent / Jones' reagent / acetone / 0.25 h / -15 - -10 °C 2: 79 percent / HC(OEt)3, p-TsOH*H2O / CH2Cl2 / 7 h / Heating 3: 88 percent / benzene; diethyl ether / 3 h / 10 - 15 °C 4: 74 percent / p-TsOH*H2O / formic acid / 7 h / 50 - 60 °C 5: 98 percent / BF3*Et2O / methanol / 2.5 h / 0 - 5 °C 6: 100 percent / NaBH4 / methanol / 2 h / Ambient temperature 7: 94 percent / Na, liq. NH3 / tetrahydrofuran / 0.5 h / -50 - -45 °C 8: 82 percent / Jones' reagent / acetone / 0.25 h / -15 - -10 °C View Scheme
参考文献
Gao, Hongwu; Su, Xiangdong; Zhou, Liming; Li, Zhensu
Organic Preparations and Procedures International, 1997 , vol. 29, # 5 p. 572 - 576
反应条件
Cylindrocarpon dydimum in water
Enzymatic reaction; Product distribution / selectivity;
参考文献
RICHTER GEDEON NYRT.
Patent: WO2008/32131 A1, 2008 ;
Location in patent: Page/Page column 12-14 ;
反应条件
1: 94 percent / Jones' reagent / acetone / 0.25 h / -15 - -10 °C
2: 79 percent / HC(OEt)3, p-TsOH*H2O / CH2Cl2 / 7 h / Heating
3: 88 percent / benzene; diethyl ether / 3 h / 10 - 15 °C
4: 74 percent / p-TsOH*H2O / formic acid / 7 h / 50 - 60 °C
View Scheme
参考文献
Gao, Hongwu; Su, Xiangdong; Huang, Lei; Li, Zhensu
Synthetic Communications, 1997 , vol. 27, # 11 p. 1981 - 1987
