2-甲基-4-甲氧基苯酚合成路线 （共 30 条）
反应条件
formic acid; hydrogen bromide; benzene Reagens 4: Essigsaeure;
参考文献
Green et al.
Journal of the Chemical Society, 1959 , p. 3362,3369
反应条件
1: With chloroformic acid ethyl ester; triethylamine in tetrahydrofuran
T=0°C; 1 h;
2: With sodium tetrahydroborate in tetrahydrofuran; water
T=20°C; 2.25 h; Cooling with ice;
3: With hydrogenchloride in tetrahydrofuran; water
pH=< 2;
参考文献
KARO BIO AB
Patent: WO2009/124968 A1, 2009 ;
Location in patent: Page/Page column 29 ;
反应条件
1,4-dioxane; copper oxide-chromium oxide catalyst
T=235°C; P=202265 Torr; Hydrogenation;
参考文献
Reeve; Sadle
Journal of the American Chemical Society, 1950 , vol. 72, p. 3252
反应条件
hydrogenchloride in methanol
T=20°C;
参考文献
Clark, Richard F.; Zhang, Tianyuan; Wang, Xiaojun; Wang, Rongqi; Zhang, Xiaolin; Camp, Heidi S.; Beutel, Bruce A.; Sham, Hing L.; Gu, Yu Gui
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 7 p. 1961 - 1965
参考文献
Selassie, Cynthia D.; Verma, Rajeshwar P.; Kapur, Sanjay; Shusterman, Alan J.; Hansch, Corwin
Journal of the Chemical Society. Perkin Transactions 2, 2002 , # 6 p. 1112 - 1117
反应条件
Amberlyst-15
4 h; Reflux; Overall yield = 71 percent;
参考文献
Mondal, Rina; Guha, Chayan; Mallik, Asok K.
Tetrahedron Letters, 2014 , vol. 55, # 1 p. 86 - 89
反应条件
poly(4-vinylpyridine-N-oxide) 2 percent cross-linked; dihydrogen peroxide; methyltrioxorhenium (VII) in ethanol; water
T=40°C;
参考文献
Saladino, Raffaele; Neri, Veronica; Mincione, Enrico; Filippone, Paolino
Tetrahedron, 2002 , vol. 58, # 42 p. 8493 - 8500
参考文献
Moran et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 127
反应条件
toluene-4-sulfonic acid
anodic oxidation;
参考文献
Nishiguchi, Ikuzo; Hirashima, Tsuneaki
Journal of Organic Chemistry, 1985 , vol. 50, # 4 p. 539 - 541
反应条件
sodium hydroxide
T=10°C;
参考文献
Kharasch et al.
Journal of Organic Chemistry, 1956 , vol. 21, p. 925,927
