2-硝基-1,4-苯二胺合成路线 （共 41 条）
反应条件
sodium hypochlorite in water
参考文献
Hodnett; Prakash
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 101 - 104
反应条件
sodium tetrahydroborate in water; isopropyl alcohol T=20°C; SolventTime;
参考文献
ARCH PHARMALABS LIMITED; MANDAL, Arun Kanti; RANBHAN, Kamlesh Jayantilal; SAXENA, Sudhanshu; GAIKWAD, Sanjay Ramrao; SARJEKAR, Pushpalata Balkrishna
Patent: WO2013/11518 A1, 2013 ;
Location in patent: Page/Page column 55-56 ;
反应条件
1: isopropyl alcohol / 75 °C 2: sodium hydroxide; sodium tetrahydroborate / 75 °C View Scheme
参考文献
Hu, Hai-Ning; Zhou, Ping-Zheng; Chen, Fei; Li, Min; Nan, Fa-Jun; Gao, Zhao-Bing
Acta Pharmacologica Sinica, 2013 , vol. 34, # 10 p. 1359 - 1366
反应条件
phosphoric acid; sulfuric acid T=-5°C; Diazotization.Behandlung der Diazoniumsalz-Loesung mit wss. KI-Loesung;
参考文献
Schoutissen
Journal of the American Chemical Society, 1933 , vol. 55, p. 4541,4544
反应条件
1: 12 g / dimethylaniline / acetonitrile / 3 h / Ambient temperature 2: 6.5 g / H2, HCl / 10percent Pd-C / methanol; propan-2-ol / 760 Torr / Ambient temperature 3: 1.1 g / sulphur / xylene / 8 h / Heating View Scheme
参考文献
Rajappa, S.; Sreenivasan, R.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 7 p. 539 - 541
反应条件
in dichloromethane
T=20°C; 48 h;
参考文献
Telik, Inc.
Patent: US2010/81653 A1, 2010 ;
Location in patent: Page/Page column 11-12 ;
US 20100081653 A1
反应条件
1: 60 percent / pyridine / benzene / 10 h / Ambient temperature
2: 80 percent / hydrogen / Raney-nickel / ethanol / 3 h
3: 60 percent / ethanol / 5 h / Heating
View Scheme
参考文献
Agrawal, Vijai K.; Sharma, Satyavan
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 2 p. 146 - 149
反应条件
triethylamine in N,N-dimethyl-formamide
4 h; Yield given;
参考文献
Kumar; Seth; Bhaduri; Visen; Misra; Gupta; Fatima; Katiyar; Chatterjee; Sen
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1083 - 1089
反应条件
sodium hypobromide in water
参考文献
Hodnett; Prakash
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 101 - 104
反应条件
1: 100 percent / CH2Cl2 / 48 h / 20 °C
2: 99 percent / H2 / Pd/C / methanol / 24 h / 20 °C
View Scheme
参考文献
Evans, Kathryn M.; Slawin, Alexandra M. Z.; Lebl, Tomas; Philp, Douglas; Westwood, Nicholas J.
Journal of Organic Chemistry, 2007 , vol. 72, # 9 p. 3186 - 3193
