3-(3,4-二氯苯基)-3-氧代丙酸乙酯合成路线 （共 3 条）
反应条件
1: 3,4-Dichlorobenzoic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran T=25°C; 4 h; 2: malonic acid ethyl ester monopotassium salt With triethylamine; magnesium chloride in tetrahydrofuran; acetonitrile T=20°C; 2 h;
参考文献
BIOENERGENIX; MCCALL, John; KELLY, Robert, C.; ROMERO, Donna, L.
Patent: WO2014/66795 A1, 2014 ;
Location in patent: Paragraph 0175 ;
反应条件
triethylamine; magnesium chloride in acetonitrile
参考文献
Takamura, Makoto; Yabu, Kazuo; Nishi, Takahide; Yanagisawa, Hiroaki; Kanai, Motomu; Shibasaki, Masakatsu
Synlett, 2003 , # 3 p. 353 - 356
反应条件
(i) nBuLi, THF, hexane, (ii) /BRN= 607485/; Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 44, # 2 p. 310 - 311
