2,2'-二甲基-p-三联苯合成路线 （共 19 条）
反应条件
1: 1-bromo-2-methyl benzene With lithium
2: With zinc(II) chloride in tetrahydrofuran; diethyl ether
T=0°C; 1 h;
3: para-dichlorobenzene With nickel phosphine amido pincer complex in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=70°C; Negishi cross-coupling; 5 h; Further stages.;
参考文献
Wang, Li; Wang, Zhong-Xia
Organic Letters, 2007 , vol. 9, # 21 p. 4335 - 4338
反应条件
Ni(Cl){2-(Ph2P)C6H4NCH(Ph)P(O)Ph2} in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=25°C; Negishi coupling reaction; 24 h; Inert atmosphere;
参考文献
Liu, Ning; Wang, Li; Wang, Zhong-Xia
Chemical Communications, 2011 , vol. 47, # 5 p. 1598 - 1600
反应条件
silver carbonate; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
Suzuki cross-coupling reaction; 16 h; Heating;
参考文献
Chaumeil, Helene; Le Drian, Claude; Defoin, Albert
Synthesis, 2002 , # 6 p. 757 - 760
反应条件
potassium carbonate in ethanol; water
T=20°C; Suzuki-Miyaura coupling; 8 h;
参考文献
Sreedhar; Yada, Divya; Reddy, P. Surendra
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 14-15 p. 2823 - 2836
反应条件
cesium fluoride; Na2[PdCl4] in methanol
T=40°C; Arylation; cross-coupling; 24 h;
参考文献
Willis; Strongin
Tetrahedron Letters, 2000 , vol. 41, # 33 p. 6271 - 6274
反应条件
C35H31BrN4NiP in tetrahydrofuran
T=70°C; 22 h; Schlenk techniqueInert atmosphere;
参考文献
Guo, Wang-Jun; Wang, Zhong-Xia
Journal of Organic Chemistry, 2013 , vol. 78, # 3 p. 1054 - 1061
反应条件
C20H23BrN4Ni in tetrahydrofuran
T=25°C; Kumada Cross-Coupling; 24 h; Inert atmosphere;
参考文献
Sun, Yunqiang; Li, Xiaoyan; Sun, Hongjian
Dalton Transactions, 2014 , vol. 43, # 25 p. 9410 - 9413
反应条件
nickel dichloride in tetrahydrofuran
T=50°C; 2 h;
参考文献
Ikoma; Ando; Naoi; Akiyama; Sugimori
Synthetic Communications, 1991 , vol. 21, # 3 p. 481 - 487
反应条件
nickel dichloride in tetrahydrofuran
T=55°C; 2 h;
参考文献
Ikoma, Yoshiharu; Taya, Fumio; Ozaki, Ei-ichi; Higuchi, Shigeki; Naoi, Yoshitake; Fuji-i, Kiyomi
Synthesis, 1990 , # 2 p. 147 - 148
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 2 h / -78 °C
1.2: triisopropylborate / tetrahydrofuran; hexane / 2 h / -78 - 20 °C
1.3: 1.36 g / aq. HCl / tetrahydrofuran; hexane
2.1: K2CO3 / Pd(PPh3)4 / benzene; ethanol / 6 h / Heating
View Scheme
参考文献
Lunazzi, Lodovico; Mazzanti, Andrea; Minzoni, Mirko; Edgar Anderson
Organic Letters, 2005 , vol. 7, # 7 p. 1291 - 1294
