N-(4-甲氧基苯基)乙烷硫代酰胺合成路线 （共 16 条）
反应条件
sodium hydroxide; potassium hexacyanoferrate(III)
参考文献
Huang, Qingqing; Mao, Jialin; Wan, Baojie; Wang, Yuehong; Brun, Reto; Franzblau, Scott G.; Kozikowski, Alan P.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 21 p. 6757 - 6767
反应条件
hydroxylamine hydrochloride; sodium acetate; dithiophosphoric acid O,O-diethyl ester in 1,4-dioxane
T=80 - 90°C; 2 h; Inert atmosphere;
参考文献
Yadav, Arvind K.; Srivastava, Vishnu P.; Yadav, Lal Dhar S.
Tetrahedron Letters, 2012 , vol. 53, # 52 p. 7113 - 7116
反应条件
Lawesson's reagent in tetrahydrofuran
T=20°C;
参考文献
Yde, B.; Yousif, N. M.; Pedersen, U.; Thomsen, I.; Lawesson, S. -O.
Tetrahedron, 1984 , vol. 40, # 11 p. 2047 - 2052
反应条件
thiophosphoryl trichloride; water; triethylamine
T=0 - 90°C; Beckmann rearrangement; chemoselective reaction;
参考文献
Pathak, Uma; Pandey, Lokesh Kumar; Mathur, Sweta; Suryanarayana
Chemical Communications, 2009 , # 36 p. 5409 - 5411
反应条件
1: NaOH-solution / 20 °C
2: beim Schmelzen
View Scheme
参考文献
Worrall
Journal of the American Chemical Society, 1924 , vol. 46, p. 2836
反应条件
1: diethyl ether / und Behandeln des Reaktionsprodukts mit Schwefelsaeure
2: NaOH-solution / 20 °C
3: beim Schmelzen
View Scheme
参考文献
Worrall
Journal of the American Chemical Society, 1924 , vol. 46, p. 2836
反应条件
in tetrahydrofuran
T=20°C; 2 h; Further byproducts given. Title compound not separated from byproducts;
参考文献
Przychodzen, Witold
Heteroatom Chemistry, 2006 , vol. 17, # 7 p. 676 - 684
反应条件
in acetonitrile
T=50°C; aminolysis of phenyl dithioacetates with anilines, N,N-dimethylanilines and benzylamines in MeCN; formation of zwitterionic tetrahedral intermediate; proton transfer; rate-limiting step; effect of nucleophile, leaving group; Rate constantMechanism;
参考文献
Oh, Hyuck Keun; Woo, So Young; Shin, Chul Ho; Park, Young Sook; Lee, Ikchoon
Journal of Organic Chemistry, 1997 , vol. 62, # 17 p. 5780 - 5784
反应条件
in acetonitrile
T=50°C; aminolysis of phenyl dithioacetates with anilines, N,N-dimethylanilines and benzylamines in MeCN; formation of zwitterionic tetrahedral intermediate; proton transfer; rate-limiting step; effect of nucleophile, leaving group; Rate constantMechanism;
参考文献
Oh, Hyuck Keun; Woo, So Young; Shin, Chul Ho; Park, Young Sook; Lee, Ikchoon
Journal of Organic Chemistry, 1997 , vol. 62, # 17 p. 5780 - 5784
反应条件
in acetonitrile
T=50°C; aminolysis of phenyl dithioacetates with anilines, N,N-dimethylanilines and benzylamines in MeCN; formation of zwitterionic tetrahedral intermediate; proton transfer; rate-limiting step; effect of nucleophile, leaving group; Rate constantMechanism;
参考文献
Oh, Hyuck Keun; Woo, So Young; Shin, Chul Ho; Park, Young Sook; Lee, Ikchoon
Journal of Organic Chemistry, 1997 , vol. 62, # 17 p. 5780 - 5784
