4-(4-硝基苯基)-2-噻唑羧酸乙酯合成路线 (共 8 条)
反应条件
in ethanol T=80°C; Hantzsch thiazole synthesis; 0.166667 h; Microwave irradiation;
参考文献
Gaikwad, Sudhakar A.; Patil, Amol A.; Deshmukh, Madhukar B.
Phosphorus, Sulfur and Silicon and the Related Elements, 2010 , vol. 185, # 1 p. 103 - 109
反应条件
in ethanol T=80°C; 19 h;
参考文献
SELEXAGEN THERAPEUTICS, INC.; VERNIER, Jean-Michel; MAY, John; O'CONNOR, Patrick; RIPKA, William; PINKERTON, Anthony; BOUNAUD, Pierre-Yves; HOPKINS, Stephanie
Patent: WO2011/85128 A1, 2011 ;
Location in patent: Page/Page column 54-55 ;
反应条件
in methanol 1 h; Heating / reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO KG
Patent: WO2004/65367 A1, 2004 ;
Location in patent: Page 136 ;
WO 2004/065367 A1
反应条件
in methanol 1 h; Heating / reflux;
参考文献
Boehringer Ingelheim (Canada) Ltd.
Patent: US2003/236251 A1, 2003 ;
Location in patent: Page 27 ;
反应条件
1: pyridinium bromide perbromide, HBr / acetic acid / 0.5 h / Ambient temperature 2: ethanol / 30 h / Heating View Scheme
参考文献
Chemical & Pharmaceutical Bulletin, , vol. 43, # 9 p. 1497 - 1504
反应条件
tin(ll) chloride in ethanol
Heating;
参考文献
Shearer, Barry G.; Chao, Esther Y.; Uehling, David E.; Deaton, David N.; Cowan, Conrad; Sherman, Bryan W.; Milliken, Tula; Faison, Walter; Brown, Kathleen; Adkison, Kimberly K.; Lee, Frank
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4670 - 4677
反应条件
1: With hydrogenchloride; SnCl2·2H2O in ethanol; water
2 h; Reflux;
2: With potassium hydroxide in ethanol; water
T=0°C;
参考文献
SELEXAGEN THERAPEUTICS, INC.; VERNIER, Jean-Michel; MAY, John; O'CONNOR, Patrick; RIPKA, William; PINKERTON, Anthony; BOUNAUD, Pierre-Yves; HOPKINS, Stephanie
Patent: WO2011/85128 A1, 2011 ;
Location in patent: Page/Page column 55 ;
反应条件
1: With hydrogenchloride; SnCl2·2H2O in ethanol; water
2 h; Reflux;
2: With potassium hydroxide in ethanol; water
T=0°C;
参考文献
SELEXAGEN THERAPEUTICS, INC.; VERNIER, Jean-Michel; MAY, John; O'CONNOR, Patrick; RIPKA, William; PINKERTON, Anthony; BOUNAUD, Pierre-Yves; HOPKINS, Stephanie
Patent: WO2011/85128 A1, 2011 ;
Location in patent: Page/Page column 55 ;