(R)-(+)-6-羟基-2,5,7,8-四甲基色满-2-羧酸合成路线 （共 20 条）
反应条件
1: With water; sodium hydroxide in methanol T=80°C; 1 h; Inert atmosphere; 2: With potassium hydrogensulfate; water in methanol T=60°C; pH=5; Product distribution / selectivity;
参考文献
Mitsubishi Gas Chemical Company, Inc.
Patent: EP2088144 A1, 2009 ;
Location in patent: Page/Page column 8; 12 ;
反应条件
1: With sodium hydroxide in water 2: With hydrogenchloride in water T=50°C;
参考文献
EP2351729 A1, ;
Page/Page column 11 ;
反应条件
1: 100 percent / H2 / 5percent Pd/C / ethyl acetate 2: concd. HCl / 2 h / 90 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 12 p. 2445 - 2450
反应条件
1: 4.9 g / KOH / methanol / 5 h / Heating 2: 0.75 g / 1N NaOH, H2 / 5percent Pd/C / H2O / 760 Torr 3: SOCl2, pyridine 5: tetrahydrofuran / a) -78 deg C, 5h, b) -20 deg C, 16h 6: 28percent NaOH / ethanol / Ambient temperature 7: 111 mg / Ce(NH4)2(NO3)6 / acetonitrile; H2O / 0.17 h / Ambient temperature View Scheme
参考文献
Helvetica Chimica Acta, , vol. 73, # 4 p. 1068 - 1086
反应条件
1: 0.75 g / 1N NaOH, H2 / 5percent Pd/C / H2O / 760 Torr 2: SOCl2, pyridine 4: tetrahydrofuran / a) -78 deg C, 5h, b) -20 deg C, 16h 5: 28percent NaOH / ethanol / Ambient temperature 6: 111 mg / Ce(NH4)2(NO3)6 / acetonitrile; H2O / 0.17 h / Ambient temperature View Scheme
参考文献
Helvetica Chimica Acta, , vol. 73, # 4 p. 1068 - 1086
反应条件
hydrogenchloride 10 h; Heating;
参考文献
Yoda, Hidemi; Takabe, Kunihiko
Chemistry Letters, 1989 , p. 465 - 466
反应条件
hydrogenchloride T=90°C; 2 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 46, # 12 p. 2445 - 2450
反应条件
3: NBS, t-BuOK / -20 deg C, 2 h, RT, 2 h 4: Bu3SnH / benzene / 10 h / 90 °C 5: 98 percent / cc. HCl / 10 h / Heating View Scheme
参考文献
Chemistry Letters, , p. 465 - 466
反应条件
2: NBS, t-BuOK / -20 deg C, 2 h, RT, 2 h 3: Bu3SnH / benzene / 10 h / 90 °C 4: 98 percent / cc. HCl / 10 h / Heating View Scheme
参考文献
Chemistry Letters, , p. 465 - 466
反应条件
1: NBS, t-BuOK / -20 deg C, 2 h, RT, 2 h 2: Bu3SnH / benzene / 10 h / 90 °C 3: 98 percent / cc. HCl / 10 h / Heating View Scheme
参考文献
Chemistry Letters, , p. 465 - 466
