3-氯-2-环戊烯-1-酮合成路线 （共 13 条）
反应条件
potassium carbonate 1 h; Ambient temperature;
参考文献
Mphahlele, Malose J.; Modro, Tomasz A.
Journal of Organic Chemistry, 1995 , vol. 60, # 25 p. 8236 - 8240
反应条件
1: 72 percent / toluene; diethyl ether / 96 h / Ambient temperature 2: 79 percent / aq.NH4Cl, KCN / benzene / 0.08 h View Scheme
参考文献
Zimmerman, Howard E.; Pasteris, Robert J.
Journal of Organic Chemistry, 1980 , vol. 45, # 24 p. 4864 - 4876
反应条件
oxalyl dichloride in dichloromethane
T=0 - 25°C; Inert atmosphere;
参考文献
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
Patent: WO2009/148654 A2, 2009 ;
Location in patent: Page/Page column 106-107 ;
反应条件
1: SOCl2
2: AlCl3 / CH2Cl2 / 1.5 h / -5 - 0 °C
3: 64 percent / NaHCO3 / CH2Cl2 / 3 h / Heating
View Scheme
参考文献
Drouin, J.; Leyendecker, F.; Conia J. M.
Tetrahedron, 1980 , vol. 36, # 82 p. 1203 - 1208
反应条件
1: AlCl3 / CH2Cl2 / 1.5 h / -5 - 0 °C
2: 64 percent / NaHCO3 / CH2Cl2 / 3 h / Heating
View Scheme
参考文献
Drouin, J.; Leyendecker, F.; Conia J. M.
Tetrahedron, 1980 , vol. 36, # 82 p. 1203 - 1208
反应条件
1: 71 percent / Cl2, HCl / dimethylformamide / 2 h / 45 - 53 °C / other reaction sequence: chlorination in CCl4, dehydrochlorination in DMF, 80 deg C, 30 min, then chlorination in DMF, 65-75 deg C, 5 h
View Scheme
参考文献
Buyck, L. De; Kimpe, N. De; Verhe, R.; Courtheyn, D.; Schamp, N.
Bulletin des Societes Chimiques Belges, 1980 , vol. 89, # 12 p. 1043 - 1060
反应条件
sodium hydroxide; aluminium trichloride; (10H)-phenothiazine; sodium carbonate
1.) CH2Cl2, -5 deg C - 0 deg C, 50 min, 2.) H2O, reflux, 2 h; Yield given. Multistep reaction;
参考文献
Drouin, J.; Conia, J. M.
Synthetic Communications, 1982 , vol. 12, # 1 p. 81 - 84
反应条件
2: dichromate; aqueous H2SO4
View Scheme
参考文献
Mousseron; Jacquier; Winternitz
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1947 , vol. 224, p. 1230
反应条件
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Buyck, L. De; Kimpe, N. De; Verhe, R.; Courtheyn, D.; Schamp, N.
Bulletin des Societes Chimiques Belges, 1980 , vol. 89, # 12 p. 1043 - 1060
反应条件
in dichloromethane
T=0°C; 1 h;
参考文献
Ullrich, John W.; Chiu, Fang-Ting; Tiner-Harding, Tammy; Mariano, Patrick S.
Journal of Organic Chemistry, 1984 , vol. 49, # 2 p. 220 - 228
