(3E,13Z)-十八碳二烯-1-基乙酸酯合成路线 （共 61 条）
反应条件
1: 98 percent / conc. sulfuric acid / 24 h / Heating
2: 70 percent / lead tetraacetate / benzene
3: n-BuLi / toluene / 2 h / 25 °C
4: lithium aluminium hydride / tetrahydrofuran / 4 h / Heating
5: PBr3
6: 98 percent / acetonitrile / 24 h / Heating
7: NaOEt / tetrahydrofuran / 1 h / 25 °C
8: n-BuLi / toluene / 2 h / 25 °C
View Scheme
参考文献
Vinczer, Peter; Juvancz, Zoltan; Novak, Lajos; Szantay, Csaba
Acta Chimica Hungarica, 1988 , vol. 125, # 6 p. 797 - 820
反应条件
1: 70 percent / lead tetraacetate / benzene
2: n-BuLi / toluene / 2 h / 25 °C
3: lithium aluminium hydride / tetrahydrofuran / 4 h / Heating
4: PBr3
5: 98 percent / acetonitrile / 24 h / Heating
6: NaOEt / tetrahydrofuran / 1 h / 25 °C
7: n-BuLi / toluene / 2 h / 25 °C
View Scheme
参考文献
Vinczer, Peter; Juvancz, Zoltan; Novak, Lajos; Szantay, Csaba
Acta Chimica Hungarica, 1988 , vol. 125, # 6 p. 797 - 820
反应条件
1: 60 percent / lead tetraacetate / benzene / 3 h / Ambient temperature
2: NaOEt / toluene / 2 h / 25 °C
3: PBr3
4: 98 percent / acetonitrile / 24 h / Heating
5: NaOEt / tetrahydrofuran / 1 h / 25 °C
6: n-BuLi / toluene / 2 h / 25 °C
View Scheme
参考文献
Vinczer, Peter; Juvancz, Zoltan; Novak, Lajos; Szantay, Csaba
Acta Chimica Hungarica, 1988 , vol. 125, # 6 p. 797 - 820
反应条件
1: PBr3
2: 98 percent / acetonitrile / 24 h / Heating
3: NaOEt / tetrahydrofuran / 1 h / 25 °C
4: n-BuLi / toluene / 2 h / 25 °C
View Scheme
参考文献
Vinczer, Peter; Juvancz, Zoltan; Novak, Lajos; Szantay, Csaba
Acta Chimica Hungarica, 1988 , vol. 125, # 6 p. 797 - 820
反应条件
1: 98 percent / acetonitrile / 24 h / Heating
2: NaOEt / tetrahydrofuran / 1 h / 25 °C
3: n-BuLi / toluene / 2 h / 25 °C
View Scheme
参考文献
Vinczer, Peter; Juvancz, Zoltan; Novak, Lajos; Szantay, Csaba
Acta Chimica Hungarica, 1988 , vol. 125, # 6 p. 797 - 820
反应条件
1: lithium aluminium hydride / tetrahydrofuran / 4 h / Heating
2: PBr3
3: 98 percent / acetonitrile / 24 h / Heating
4: NaOEt / tetrahydrofuran / 1 h / 25 °C
5: n-BuLi / toluene / 2 h / 25 °C
View Scheme
参考文献
Vinczer, Peter; Juvancz, Zoltan; Novak, Lajos; Szantay, Csaba
Acta Chimica Hungarica, 1988 , vol. 125, # 6 p. 797 - 820
反应条件
1: NaOEt / tetrahydrofuran / 1 h / 25 °C
2: n-BuLi / toluene / 2 h / 25 °C
View Scheme
参考文献
Vinczer, Peter; Juvancz, Zoltan; Novak, Lajos; Szantay, Csaba
Acta Chimica Hungarica, 1988 , vol. 125, # 6 p. 797 - 820
反应条件
1: 77 percent / triethylamine / CH2Cl2 / 2 h
2: 1.) Mg, 2.) Li2CuCl4 / 1.) THF, -10 deg, 30 min, 2.) THF, -10 deg C, 3 h
3: 61 percent / pyridinium p-toluenosulphonate / methanol / 6 h / 55 °C
4: 77 percent / LiAlH4 / bis-(2-methoxy-ethyl) ether / 8 h / Heating
5: 85 percent / pyridine / CH2Cl2 / 5 h / Ambient temperature
View Scheme
参考文献
Trehan, I R; Kad, G L; Singh, Vasundhara; Vig, Rakesh
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1991 , vol. 30, # 6 p. 563 - 566
反应条件
1: 1.) Mg, 2.) Li2CuCl4 / 1.) THF, -10 deg, 30 min, 2.) THF, -10 deg C, 3 h
2: 61 percent / pyridinium p-toluenosulphonate / methanol / 6 h / 55 °C
3: 77 percent / LiAlH4 / bis-(2-methoxy-ethyl) ether / 8 h / Heating
4: 85 percent / pyridine / CH2Cl2 / 5 h / Ambient temperature
View Scheme
参考文献
Trehan, I R; Kad, G L; Singh, Vasundhara; Vig, Rakesh
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1991 , vol. 30, # 6 p. 563 - 566
反应条件
in pyridine; diethyl ether
T=25°C; 5 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Vinczer, Peter; Baan, Gabor; Juvancz, Zoltan; Novak, Lajos; Szantay, Csaba
Synthetic Communications, 1985 , vol. 15, # 14 p. 1257 - 1270
