1: 95 percent / 30percent hydrogen peroxide, 3 M aq. lithium hydroxide / methanol / 5 h / -30 - -25 °C 2: aq. sodium hydrogen carbonate, aluminium amalgam / tetrahydrofuran; methanol / 1.) 10 deg C, 2 h, 2.) room temperature, 4 h 3: 80 percent / K-Selectride / tetrahydrofuran / 5 h / -50 - -45 °C 4: hydrofluoric acid / acetonitrile / 1 h / -5 °C 5: base hydrolysis View Scheme

1: 95 percent / 30percent hydrogen peroxide, 3 M aq. lithium hydroxide / methanol / 5 h / -30 - -25 °C 2: aq. sodium hydrogen carbonate, aluminium amalgam / tetrahydrofuran; methanol / 1.) 10 deg C, 2 h, 2.) room temperature, 4 h 3: 80 percent / K-Selectride / tetrahydrofuran / 5 h / -50 - -45 °C 4: hydrofluoric acid / acetonitrile / 1 h / -5 °C View Scheme

1: 1.) aq. H2O2, 1N NaOH, 2.) aluminum amalgam / 1.) methanol, -10-0 deg C, 2 h 2: 83 percent / morphilinosulfotrifluoride / CH2Cl2 / 1 h / -78 °C 3: 75 percent / aq. acetic acid, 1N HCl / tetrahydrofuran / 30 h / 25 °C 4: alkaline medium View Scheme