2-甲基-4-羟基嘧啶-5-羧酸乙酯合成路线 （共 10 条）
反应条件
hydrogenchloride in ethanol; dichloromethane; sodium ethanolate; ethyl acetate
参考文献
Corvas International, Inc.
Patent: US5656645 A1, 1997 ;
US 5656645 A
反应条件
sodium ethanolate in ethanol T=20 - 60°C; 6.0833 h; Inert atmosphere;
参考文献
AstraZeneca AB
Patent: US2009/264401 A1, 2009 ;
Location in patent: Page/Page column 117 ;
参考文献
Corvas International, Inc.
Patent: US6011158 A1, 2000 ;
反应条件
ethanol; sodium ethanolate Heating;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 3 p. 403 - 406
参考文献
Yakugaku Zasshi, , vol. 67, p. 204
Chem.Abstr., , p. 9063
反应条件
1: POCl3 2: NH3 View Scheme
参考文献
Todd; Bergel
Journal of the Chemical Society, 1937 , p. 367
Journal of the Chemical Society, 1938 , p. 28
反应条件
1: POCl3 2: NH3 3: NH3 4: POCl3 View Scheme
参考文献
Todd; Bergel
Journal of the Chemical Society, 1937 , p. 367
Journal of the Chemical Society, 1938 , p. 28
反应条件
trichlorophosphate 0.5 h; Reflux;
参考文献
AstraZeneca AB
Patent: US2009/264401 A1, 2009 ;
Location in patent: Page/Page column 117-118 ;
反应条件
1: POCl3
2: NH3
3: NH3
View Scheme
参考文献
I.G.Farbenind.
Patent: DE670095 , 1936 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 25, p. 435
反应条件
1: POCl3
2: NaHS
3: aqueous NaOH
View Scheme
参考文献
Sawa et al.
Shionogi Kenkyusho Nenpo, 1952 , # 2 p. 76,78
Chem.Abstr., 1957 , p. 10008
