(E)-1-溴-3-辛烯合成路线 （共 10 条）
反应条件
1: 1) Mg, 2) Li2CuCl4 / 1) THF, 2) THF, a) -70 deg C to 20 deg C over 45 min, b) 2 h at 20 deg C 2: 92 percent / TsOH*Py / methanol / 3 h / 45 °C View Scheme
参考文献
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , vol. 39, # 11 p. 2296 - 2300
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 11 p. 2539 - 2544
反应条件
(i) Mg, (ii) /BRN= 1900390/; Multistep reaction;
参考文献
Julia,M. et al.
Bulletin de la Societe Chimique de France, 1961 , p. 1849 - 1853
反应条件
1: 1-bromo-4-methoxy-benzene With magnesium in tetrahydrofuran Heating; 2: (E)-1-oct-3-enyl bromide With lithium tetrachlorocuprate in tetrahydrofuran Grignard reaction;
参考文献
Vyvyan, James R.; Holst, Christian L.; Johnson, Allison J.; Schwenk, Cheryl M.
Journal of Organic Chemistry, 2002 , vol. 67, # 7 p. 2263 - 2265
反应条件
magnesium in diethyl ether
参考文献
Ivanova, N. M.; Cheskis, B. A.; Rubanova, E. V.; Yatsynin, V. G.; Moiseenkov, A. M.; Nefedov, O. M.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1991 , vol. 40, # 3.2 p. 557 - 561
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1991 , # 3 p. 640 - 644
反应条件
1: 1) Mg, 2) Li2CuCl4 / 1) THF, 2) THF, -70 deg C to 20 deg C
2: 97 percent / TsOH*Py / methanol / 45 °C
View Scheme
参考文献
Cheskis, B. A.; Ivanova, N. M.; Moiseenkov, A. M.; Nefedov, O. M.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1990 , vol. 39, # 11 p. 2296 - 2300
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1990 , # 11 p. 2539 - 2544
反应条件
1: 1.) Li, ferric chloride, liquid ammonia / 1.) THF, 1 h, 2.) DMSO, -35 deg C, 3 h
2: TsOH, H2O / methanol / 24 h / Ambient temperature
View Scheme
参考文献
Odinokov, V. N.; Ishmuratov, G. Yu.; Ladenkova, I. M.; Botsman, L. P.; Kargapol'tseva, T. A.; Tolstikov, G. A.
Chemistry of Natural Compounds, 1991 , vol. 27, # 5 p. 621 - 623
Khimiya Prirodnykh Soedinenii, 1991 , # 5 p. 704 - 707
反应条件
1: 1) Mg, 2) Li2CuCl4 / 1) THF, 2) THF, a) -70 deg C to 20 deg C over 45 min, b) 2 h at 20 deg C
2: 92 percent / TsOH*Py / methanol / 3 h / 45 °C
3: 84 percent / pyridinium chlorochromate / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Cheskis, B. A.; Ivanova, N. M.; Moiseenkov, A. M.; Nefedov, O. M.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1990 , vol. 39, # 11 p. 2296 - 2300
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1990 , # 11 p. 2539 - 2544
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; dilithium tetrachlorocuprate in tetrahydrofuran
T=-70 - 0°C; 1 h;
参考文献
Moiseenkov, Alexander M.; Czeskis, Boris A.; Ivanova, Natalya M.; Nefedov, Oleg M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , p. 2639 - 2649
反应条件
dilithium tetrachlorocuprate; ethylmagnesium bromide
1.) THF, 40-50 deg C, 2.) THF, HMPA, from -70 deg C to 0 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Cheskis, B. A.; Ivanova, N. M.; Moiseenkov, A. M.; Nefedov, O. M.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1991 , vol. 40, # 7 p. 1372 - 1380
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1991 , # 7 p. 1555 - 1562
反应条件
dilithium tetrachlorocuprate; magnesium
1) THF, 2) THF, -70 deg C to 20 deg C; Yield given. Multistep reaction;
参考文献
Cheskis, B. A.; Ivanova, N. M.; Moiseenkov, A. M.; Nefedov, O. M.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1990 , vol. 39, # 11 p. 2296 - 2300
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1990 , # 11 p. 2539 - 2544
