1: With sodium hydroxide; water in tetrahydrofuran; methanol
25 h;
2: With hydrogenchloride in tetrahydrofuran; methanol; water
参考文献
BRISTOL-MYERS SQUIBB COMPANY; ORWAT, Michael J.; PINTO, Donald J.P.; SMITH II, Leon M.; SRIVASTAVA, Shefali; CORTE, James R.
Patent: WO2013/55984 A1, 2013 ;
Location in patent: Paragraph 00287 ;