4'-氯-5-甲氧基-3-联苯乙酸甲酯合成路线 （共 16 条）
反应条件
1: (i) NaOMe, MeOH, (ii) aq. NaOH, (iii) aq. HCl
2: POCl3, Na2CO3 / toluene
3: Na / toluene
4: Br2 / benzene
View Scheme
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
1: POCl3, Na2CO3 / toluene
2: Na / toluene
3: Br2 / benzene
View Scheme
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
1: Na / toluene
2: Br2 / benzene
View Scheme
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
1: aq. NaOH
2: (i) NaOMe, MeOH, (ii) aq. NaOH, (iii) aq. HCl
3: POCl3, Na2CO3 / toluene
4: Na / toluene
5: Br2 / benzene
View Scheme
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
1: aq. NaOH / methanol
2: aq. HBr, AcOH
3: H2SO4 / benzene
View Scheme
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
1: aq. NaOH / methanol
2: aq. HBr, AcOH
View Scheme
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
lithium aluminium tetrahydride in diethyl ether
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
1: LiAlH4 / diethyl ether
2: PBr3 / CCl4
3: ethanol
4: aq. H2SO4 / acetic acid
View Scheme
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
1: aq. NaOH / methanol
2: (i) SOCl2, benzene, (ii) aq. NH3
View Scheme
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
