2-氨基-5-甲硫基-1,3,4-噻二唑合成路线 （共 13 条）
反应条件
in potassium hydroxide; ethanol; water; dimethyl sulfate
参考文献
EP883611 B1, ;
US5736545 A1, ;
反应条件
1: 5-amino-2-mercapto-1,3,4-thiadiazole With potassium hydroxide in ethanol 0.166667 h; 2: methyl bromide in ethanol 2 h;
参考文献
Gao, Yaojun; Samanta, Sanjay; Cui, Taian; Lam, Yulin
ChemMedChem, 2013 , vol. 8, # 9 p. 1554 - 1560
参考文献
Clerici; Pocar; Guido; Loche; Perlini; Brufani
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 931 - 936
参考文献
Chemische Berichte, , vol. 54, p. 2110
反应条件
sodium hydroxide in methanol; water T=20°C; 10 h;
参考文献
Chinese Chemical Letters, , vol. 23, # 7 p. 817 - 819
反应条件
ethanol Ueber die Konst. des Edukts s. Arndt, Bielich, B. 56, 2280;
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. <2> 93, p. 357
参考文献
Chemistry of Heterocyclic Compounds (New York, NY, United States), , vol. 29, # 8 p. 981 - 982
Khimiya Geterotsiklicheskikh Soedinenii, , # 8 p. 1146 - 1147
参考文献
Chemische Berichte, , vol. 54, p. 2110
参考文献
Chemische Berichte, , vol. 56, p. 2281
反应条件
1: in butan-1-ol Reflux; 2: With N-ethyl-N,N-diisopropylamine in butan-1-ol
参考文献
MERCK PATENT GMBH; HOELZEMANN, Guenter; GREINER, Hartmut; ROSSIGNOL, Emilie; SWINNEN, Dominique
Patent: WO2010/12345 A1, 2010 ;
Location in patent: Page/Page column 55 ;
WO 2010/012345 A1
