3,4,5-三甲氧基苯乙醛合成路线 （共 19 条）
反应条件
1: 99.5 percent / n-BuLi / tetrahydrofuran; hexane / 14 h / Ambient temperature 2: 73.6 percent / POCl3 / 14 h / Ambient temperature 3: 100 percent / NH2OH*HCl, AcONa / ethanol / 14 h / Ambient temperature 4: 93.5 percent / Ac2O / 2 h / Heating 5: 1.) NaOEt / 1.) ethanol, RT, 20 min, 2.) ethanol, reflux, 12 h View Scheme
参考文献
Harada, Kenichi; Choshi, Tominari; Sugino, Eiichi; Sato, Kohichi; Hibino, Satoshi
Heterocycles, 1994 , vol. 38, # 5 p. 1119 - 1126
反应条件
2: acetic acid anhydride View Scheme
参考文献
Chemische Berichte, , vol. 67, p. 696,702
反应条件
2: acetic acid anhydride 3: palladium; sulfuric acid; acetic acid / Hydrogenation View Scheme
参考文献
Hahn; Wassmuth
Chemische Berichte, 1934 , vol. 67, p. 696,702
反应条件
hydrogenchloride in water; acetone
T=25°C;
参考文献
Gemma, Sandra; Brogi, Simone; Patil, Pradeep R.; Giovani, Simone; Lamponi, Stefania; Cappelli, Andrea; Novellino, Ettore; Brown, Alan; Higgins, Matthew K.; Mustafa, Khairul; Szestak, Tadge; Craig, Alister G.; Campiani, Giuseppe; Butini, Stefania; Brindisi, Margherita
RSC Advances, 2014 , vol. 4, # 9 p. 4769 - 4781
反应条件
Dess-Martin periodane in dichloromethane
T=25°C; 1 h;
参考文献
Labruere, Raphael; Gautier, Benoit; Testud, Marlene; Seguin, Johanne; Lenoir, Christine; Desbene-Finck, Stephanie; Helissey, Philippe; Garbay, Christiane; Chabot, Guy G.; Vidal, Michel; Giorgi-Renault, Sylviane
ChemMedChem, 2010 , vol. 5, # 12 p. 2016 - 2025
反应条件
(i) (COCl)2, (ii) H2, quinoline, sulfur, Pd-BaSO4, xylene; Multistep reaction;
参考文献
Scott,A.I. et al.
Tetrahedron, 1965 , vol. 21, p. 3605 - 3631
反应条件
dichloro bis(acetonitrile) palladium(II); water; oxygen; copper dichloride in toluene; tert-butyl alcohol
T=60°C; Wacker Oxidation; P=6000.6 Torr; 1 h; Flow reactor;
参考文献
Bourne; Ley
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 10 p. 1905 - 1910
反应条件
oxygen; ozone; ethyl acetate
T=-15°C; und anschliessende Hydrierung an Palladium/Calciumcarbonat unter Kuehlung; Isolierung als Natriumhydrogensulfit-Addukt;
参考文献
Hahn; Wassmuth
Chemische Berichte, 1934 , vol. 67, p. 696,702
参考文献
Haridas, K.; Dev, Sukh
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 1018 - 1020
反应条件
1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C
1.2: 6 h / 0 - 25 °C
2.1: hydrogenchloride / acetone; water / 25 °C
View Scheme
参考文献
Gemma, Sandra; Brogi, Simone; Patil, Pradeep R.; Giovani, Simone; Lamponi, Stefania; Cappelli, Andrea; Novellino, Ettore; Brown, Alan; Higgins, Matthew K.; Mustafa, Khairul; Szestak, Tadge; Craig, Alister G.; Campiani, Giuseppe; Butini, Stefania; Brindisi, Margherita
RSC Advances, 2014 , vol. 4, # 9 p. 4769 - 4781
