2-(溴甲基)-3-甲基喹喔啉合成路线 （共 7 条）
反应条件
2-Nitropropane; sodium methylate in methanol T=20°C; 4 h;
参考文献
Chen, Yu-Jen; Hung, Hao-Chih; Sha, Chin-Kang; Chung, Wen-Sheng
Tetrahedron, 2010 , vol. 66, # 1 p. 176 - 182
反应条件
in ethanol T=0°C; 3 h;
参考文献
Butera, John A.; Spinelli, Walter; Anantharaman, Viji; Marcopulos, Nicholas; Parsons, Roderick W.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3212 - 3228
反应条件
N-bromosuccinmide; dibenzoyl peroxide in 1,2-dichloro-benzene
T=60°C; 2.5 h; Inert atmosphere;
参考文献
Chen, Yu-Jen; Hung, Hao-Chih; Sha, Chin-Kang; Chung, Wen-Sheng
Tetrahedron, 2010 , vol. 66, # 1 p. 176 - 182
反应条件
manganese(IV) oxide in chloroform
T=60°C; 6 h;
参考文献
Goswami, Shyamaprosad; Jana, Subrata; Dey, Swapan; Adak, Avijit Kumar
Chemistry Letters, 2005 , vol. 34, # 2 p. 194 - 195
反应条件
in tetrahydrofuran
T=0 - 20°C; 17 h;
参考文献
Liu, Gu; Botting, Catherine H.; Evans, Kathryn M.; Walton, Jeffrey A. G.; Xu, Guogang; Slawin, Alexandra M. Z.; Westwood, Nicholas J.
ChemMedChem, 2010 , vol. 5, # 1 p. 41 - 45
反应条件
bromine
1) MeOH, 2) MeOH, 0.5 d, r.t.; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Sarodnick, Gerhard; Kempter, Gerhard
Zeitschrift fuer Chemie (Stuttgart, Germany), 1982 , vol. 22, # 8 p. 300 - 301
反应条件
1: 50 percent / 7 h
2: 69 percent / K2CO3 / methanol; H2O / 0.5 h
3: 84 percent / 2 n HCl / 0.17 h
4: methanol / 0.5 h
5: 90 percent / Na, EtOH / 1 h / Heating
View Scheme
参考文献
Vogel, M.; Lippmann, E.
Journal fuer Praktische Chemie (Leipzig), 1987 , vol. 329, # 1 p. 101 - 107
