AlCl3, aluminium chloride in 1,4-dioxane T=20°C; 3.5 h;

Stage #1: <a href="#" onclick="return RXDsubstances(event, this, '742313', constants.ctx, '0')">1-(4-methoxyphenyl)ethanone</a> <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '906717', constants.ctx, '0')">lithium diisopropyl amide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1730733', constants.ctx, '0')">hexane</a> <br />0.5&nbsp;h;&nbsp;&nbsp;cooling;&nbsp;<br />Stage #2: <a href="#" onclick="return RXDsubstances(event, this, '741873', constants.ctx, '0')">prenyl bromide</a> T=-20 - 20&deg;C;&nbsp;4.75&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1.1: magnesium; ethylene dibromide / diethyl ether / 2 h / 0 &deg;C / |Inert atmosphere<br />1.2: 18 h / 0 - 20 &deg;C / |Inert atmosphere<br />2.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 16 h / -78 - 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1.1: magnesium; ethylene dibromide / diethyl ether / 2 h / 0 &deg;C / |Inert atmosphere<br />1.2: 18 h / 0 - 20 &deg;C / |Inert atmosphere<br />2.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 16 h / -78 - 20 &deg;C<br /> <br /> &nbsp;