3-乙氧基-2-环己烯-1-酮合成路线 （共 132 条）
反应条件
lithium diisopropyl amide
1) THF, 30 min, -78 deg C 2) -> room temperature, 2h; Yield given. Multistep reaction;
参考文献
Padwa, Albert; Haffmanns, Gunter; Tomas, Miguel
Journal of Organic Chemistry, 1984 , vol. 49, # 18 p. 3314 - 3322
反应条件
oxygen in isopropyl alcohol
T=80°C; 1 h;
参考文献
Hirao, Toshikazu; Mori, Makoto; Ohshiro, Yoshiki
Journal of Organic Chemistry, 1990 , vol. 55, # 1 p. 358 - 360
参考文献
Fischer, Evelyn; Gleiter, Rolf
Angewandte Chemie, 1989 , vol. 101, # 7 p. 925 - 927
反应条件
1: diethyl ether / -40 °C / Destillation des nach der Hydrolyse erhaltenen Reaktionsprodukts mit Wasser-Dampf
2: ethanol; platinum / Hydrogenation
View Scheme
参考文献
Woods et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 2028
反应条件
1: 2-(phenyl)ethyl bromide With magnesium in tetrahydrofuran
T=60°C; 15 h;
2: 3-ethoxy-2-cyclohexen-1-one in tetrahydrofuran
T=20°C; 34 h;
参考文献
Martin, Nolwenn J. A.; List, Benjamin
Journal of the American Chemical Society, 2006 , vol. 128, # 41 p. 13368 - 13369
反应条件
in tetrahydrofuran
T=20°C; 16 h;
参考文献
Jurkauskas, Valdas; Sadighi, Joseph P.; Buchwald, Stephen L.
Organic Letters, 2003 , vol. 5, # 14 p. 2417 - 2420
反应条件
1: diethyl ether / -40 °C / Destillation des nach der Hydrolyse erhaltenen Reaktionsprodukts mit Wasser-Dampf
View Scheme
参考文献
Woods et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 2028
反应条件
1.1: tetrahydrofuran / 1 h / 0 - 20 °C
1.2: 20 °C
2.1: N-Trimethylamine hydrochloride / water; N,N-dimethyl-formamide / 6 h / 93 °C
View Scheme
参考文献
Wu, Yong-Jin; He, Huan; Bertekap, Robert; Westphal, Ryan; Lelas, Snjezana; Newton, Amy; Wallace, Tanya; Taber, Matthew; Davis, Carl; MacOr, John E.; Bronson, Joanne
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 8 p. 2217 - 2228
反应条件
2: 68 percent / NaHCO3 / Pd(OAc)2(Ph3)2 (5percent) / dimethylformamide / 36 h / 80 °C
View Scheme
参考文献
O'Connor, Brian; Zhang, Yantao; Negishi, Ei-ichi
Tetrahedron Letters, 1988 , vol. 29, # 32 p. 3903 - 3906
反应条件
1: 1.) Mg, HgCl2 / 1.) a) THF, b) RT, 1 h, 2.) ether, 0 deg C
2: 50 percent / dimethylsulfoxide; tetrahydrofuran / Ambient temperature
View Scheme
参考文献
Smith, Amos B.; Jerris, Paula J
Journal of Organic Chemistry, 1982 , vol. 47, # 10 p. 1845 - 1855
