3-乙氧基-2-环己烯-1-酮合成路线 （共 132 条）
反应条件
1: isopropenyl bromide With tert.-butyl lithium in diethyl ether; pentane
T=-78°C; 0.416667 h; Inert atmosphere;
2: 3-ethoxy-2-cyclohexen-1-one in diethyl ether; pentane
T=-78 - 20°C; Inert atmosphere;
参考文献
Tissot, Matthieu; Poggiali, Daniele; Henon, Helene; Mueller, Daniel; Guenee, Laure; Mauduit, Marc; Alexakis, Alexandre
Chemistry - A European Journal, 2012 , vol. 18, # 28 p. 8731 - 8747
反应条件
1: 3-ethoxy-2-cyclohexen-1-one With lithium diisopropyl amide in tetrahydrofuran; hexane
T=-78°C; 1 h;
2: methyl iodide in tetrahydrofuran; hexane
T=-78 - 25°C; 1 h;
参考文献
Trost, Barry M.; Bream, Robert N.; Xu, Jiayi
Angewandte Chemie - International Edition, 2006 , vol. 45, # 19 p. 3109 - 3112
反应条件
in diethyl ether
1.) 0 deg C, 30 min, 2.) r.t., 2 h;
参考文献
Hungerford, Natasha L.; Kitching, William
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 11 p. 1839 - 1858
反应条件
1: n-butyllithium; para-bromobenzonitrile in tetrahydrofuran; hexane
T=-70°C; 1 h;
2: 3-ethoxy-2-cyclohexen-1-one in tetrahydrofuran; hexane
T=-70°C; 2 h;
3: With hydrogenchloride in tetrahydrofuran; hexane
T=20°C; 1.5 h;
参考文献
Zimmerman, Howard E.; Nesterov, Evgueni E.
Journal of the American Chemical Society, 2003 , vol. 125, # 18 p. 5422 - 5430
反应条件
diethyl ether
Eintragen des Reaktionsgemisches in wss. H2SO4 und anschliessend Destillieren mit Wasser-Dampf;
参考文献
Henon, Helene; Mauduit, Marc; Alexakis, Alexandre
Angewandte Chemie - International Edition, 2008 , vol. 47, # 47 p. 9122 - 9124
参考文献
Barnier, Jean-Pierre; Morisson, Veronique; Volle, Isabelle; Blanco, Luis
Tetrahedron Asymmetry, 1999 , vol. 10, # 6 p. 1107 - 1117
反应条件
magnesium
1) THF; Multistep reaction;
参考文献
Rawal, Viresh H.; Newton, Randall C.; Krishnamurthy, Venkat
Journal of Organic Chemistry, 1990 , vol. 55, # 18 p. 5181 - 5183
反应条件
in tetrahydrofuran; diethyl ether
T=20°C; 28 h;
参考文献
Martin, Nolwenn J. A.; List, Benjamin
Journal of the American Chemical Society, 2006 , vol. 128, # 41 p. 13368 - 13369
反应条件
1: in tetrahydrofuran
T=20°C; 48 h;
2: With hydrogenchloride; water in tetrahydrofuran
参考文献
Scheuermann Nee Taylor, Caroline J.; Jaekel, Christoph
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 17 p. 2708 - 2714
反应条件
diethyl ether
Eintragen des Reaktionsgemisches in wss. H2SO4 und anschliessend Destillieren mit Wasser-Dampf;
参考文献
Tissot, Matthieu; Poggiali, Daniele; Henon, Helene; Mueller, Daniel; Guenee, Laure; Mauduit, Marc; Alexakis, Alexandre
Chemistry - A European Journal, 2012 , vol. 18, # 28 p. 8731 - 8747
