(2H)1,4-苯并噻嗪-3(4H)-酮合成路线 （共 80 条）
反应条件
1: KOH / acetone 2: SOCl2 / CH2Cl2 4: NaOMe / methanol View Scheme
参考文献
Worley,J.W. et al.
Journal of Organic Chemistry, 1975 , vol. 40, p. 1731 - 1734
反应条件
sodium hydride in N,N-dimethyl-formamide
参考文献
Katekar,G.F.
Australian Journal of Chemistry, 1972 , vol. 25, p. 1283 - 1291
反应条件
1: 76 percent / NaNH2 / dimethylformamide / 0.75 h / 28 - 30 °C
2: 83 percent / KOH / ethanol / 0.17 h / Heating
View Scheme
参考文献
Chande; Suryanarayan
Chemistry of Heterocyclic Compounds, 2003 , vol. 39, # 8 p. 1094 - 1098
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; silica gel in acetonitrile
0.15 h; Irradiation;
参考文献
Huang, Zhi-Zhen; Zu, Liu-Sheng
Organic Preparations and Procedures International, 1996 , vol. 28, # 1 p. 121 - 123
反应条件
potassium tert-butylate
DMF, 1.) room temp., 15 min, 2.) room temp., overnight; Yield given. Multistep reaction;
参考文献
Marfat, Anthony; Carta, Michael P.
Synthesis, 1987 , # 5 p. 515 - 517
反应条件
sodium methylate in N,N-dimethyl-formamide
3 h; Heating;
参考文献
McCarthy, Eileen T.; Tyndall, D. Vivian; Meegan, Mary J.
Journal of Chemical Research, Miniprint, 1988 , # 5 p. 1332 - 1352
反应条件
1: SOCl2 / CH2Cl2
3: NaOEt / ethanol; H2O
View Scheme
参考文献
Worley,J.W. et al.
Journal of Organic Chemistry, 1975 , vol. 40, p. 1731 - 1734
反应条件
1: 3,4-dihydro-2H-1,4-benzothiazin-3(4H)-one With sodium hydride in N,N-dimethyl-formamide
T=0 - 40°C; 0.5 h;
2: bromoacetic acid methyl ester in N,N-dimethyl-formamide
T=1 - 40°C; 2.5 h;
参考文献
Japan Tobacco Inc.
Patent: US2007/197512 A1, 2007 ;
Location in patent: Page/Page column 42 ;
反应条件
hydrazine hydrate in methanol
2 h; Heating;
参考文献
Deshmukh; Jagtap; Mulik
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2007 , vol. 46, # 5 p. 852 - 859
反应条件
1: 1.) POCl3, 2.) triethylamine / 1.) acetonitrile, RT, 15 min, 2.) 5 deg C, 15 min
2: sodium azide / 3 h / Heating
View Scheme
参考文献
Reddy Sastry; Srinivasa Rao; Krishnan; Rastog i; Jain; Narayan; Reddi; Singh; Sesh agiri Rao; Junnarkar
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1990 , vol. 29, # 4 p. 396 - 398
