(2H)1,4-苯并噻嗪-3(4H)-酮合成路线 （共 80 条）
反应条件
1: 99 percent / p-methoxyphenylthiophosphine sulfide dimer / toluene / 1 h / 100 °C
2: 100 percent / potassium hydroxide powder / tetra-n-butylammonium bromide / tetrahydrofuran / 1 h / Ambient temperature
3: 67 percent / butan-1-ol / 0.5 h / Heating
View Scheme
参考文献
Shridhar, D. R.; Jogibhukta, M.; Joshi, P. P; Vishwakarma, L. C.; Narayan, G. K. A. S. S.; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 6 p. 474 - 476
反应条件
1: 90 percent / P2S5/Et3N / acetonitrile
2: K2CO3 / acetone / 8 h / Heating
3: 53 percent / ethanol / Ambient temperature
View Scheme
参考文献
Shridhar, D. R.; Jogibhukta, M.; Joshi, P. P; Vishwakarma, L. C.; Narayan, G. K. A. S. S.; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 6 p. 474 - 476
反应条件
1: 90 percent / P2S5/Et3N / acetonitrile
2: K2CO3 / acetone / 8 h / Heating
3: 90 percent / ethanol / Ambient temperature
View Scheme
参考文献
Shridhar, D. R.; Jogibhukta, M.; Joshi, P. P; Vishwakarma, L. C.; Narayan, G. K. A. S. S.; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 6 p. 474 - 476
反应条件
1: 90 percent / P2S5/Et3N / acetonitrile
2: K2CO3 / acetone / 8 h / Heating
3: 58 percent / ethanol / Ambient temperature
View Scheme
参考文献
Shridhar, D. R.; Jogibhukta, M.; Joshi, P. P; Vishwakarma, L. C.; Narayan, G. K. A. S. S.; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 6 p. 474 - 476
反应条件
1: 99 percent / p-methoxyphenylthiophosphine sulfide dimer / toluene / 1 h / 100 °C
2: 100 percent / potassium hydroxide powder / tetra-n-butylammonium bromide / tetrahydrofuran / 1 h / Ambient temperature
3: 50 percent / butan-1-ol / 0.5 h / Heating
View Scheme
参考文献
Shridhar, D. R.; Jogibhukta, M.; Joshi, P. P; Vishwakarma, L. C.; Narayan, G. K. A. S. S.; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 6 p. 474 - 476
反应条件
trichlorophosphate in ethanol
1 h; Reflux;
参考文献
Maheshwari, Monika; Yadav, Mithlesh; Pathak, Devendra
Indian Journal of Heterocyclic Chemistry, 2010 , vol. 20, # 2 p. 145 - 148
反应条件
sodium methylate in N,N-dimethyl-formamide
3 h; Heating;
参考文献
McCarthy, Eileen T.; Tyndall, D. Vivian; Meegan, Mary J.
Journal of Chemical Research, Miniprint, 1988 , # 5 p. 1332 - 1352
反应条件
chlorosulfonic acid
T=0 - 45°C; 3 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/14580 A1, 2006 ;
Location in patent: Page/Page column 36 ;
反应条件
sulfuryl dichloride in dichloromethane
参考文献
Molteni, Valentina; He, Xiaohui; Nabakka, Juliet; Yang, Kunyong; Kreusch, Andreas; Gordon, Perry; Bursulaya, Badry; Warner, Ian; Shin, Tanya; Biorac, Tanya; Ryder, Neil S.; Goldberg, Ron; Doughty, John; He, Yun
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 6 p. 1477 - 1481
反应条件
1: 99 percent / SO2Cl2 / CH2Cl2
2: 79 percent / 100 °C
3: 72 percent / NaOMe
View Scheme
参考文献
Worley,J.W. et al.
Journal of Organic Chemistry, 1975 , vol. 40, p. 1731 - 1734
