(2H)1,4-苯并噻嗪-3(4H)-酮合成路线 （共 80 条）
反应条件
1: SOCl2 / CH2Cl2
3: NaOMe / methanol
View Scheme
参考文献
Worley,J.W. et al.
Journal of Organic Chemistry, 1975 , vol. 40, p. 1731 - 1734
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=28 - 30°C; 5 h;
参考文献
Chande; Suryanarayan
Chemistry of Heterocyclic Compounds, 2003 , vol. 39, # 8 p. 1094 - 1098
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; silica gel in acetonitrile
0.166667 h; Irradiation;
参考文献
Huang, Zhi-Zhen; Zu, Liu-Sheng
Organic Preparations and Procedures International, 1996 , vol. 28, # 1 p. 121 - 123
反应条件
potassium tert-butylate
DMF, 1.) room temp., 15 min, 2.) room temp., overnight; Yield given. Multistep reaction;
参考文献
Marfat, Anthony; Carta, Michael P.
Synthesis, 1987 , # 5 p. 515 - 517
反应条件
1: 3,4-dihydro-2H-1,4-benzothiazin-3(4H)-one With tris-(dibenzylideneacetone)dipalladium(0); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; lithium hexamethyldisilazane in tetrahydrofuran; m-xylene
T=20°C; 0.166667 h; Inert atmosphere;
2: bromobenzene in tetrahydrofuran; m-xylene
T=150°C; 1 h; Inert atmosphereMicrowave irradiation; Reagent/catalystTemperatureSolvent;
参考文献
Huang, Wei-Sheng; Xu, Rongsong; Dodd, Rory; Shakespeare, William C.
Tetrahedron Letters, 2014 , vol. 55, # 2 p. 441 - 444
反应条件
1: 3,4-dihydro-2H-1,4-benzothiazin-3(4H)-one With tris-(dibenzylideneacetone)dipalladium(0); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; lithium hexamethyldisilazane in tetrahydrofuran; m-xylene
T=20°C; 0.166667 h; Inert atmosphere;
2: iodobenzene in tetrahydrofuran; m-xylene
T=150°C; 1 h; Inert atmosphereMicrowave irradiation;
参考文献
Huang, Wei-Sheng; Xu, Rongsong; Dodd, Rory; Shakespeare, William C.
Tetrahedron Letters, 2014 , vol. 55, # 2 p. 441 - 444
反应条件
1: 3,4-dihydro-2H-1,4-benzothiazin-3(4H)-one With tris-(dibenzylideneacetone)dipalladium(0); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; lithium hexamethyldisilazane in tetrahydrofuran; m-xylene
T=20°C; 0.166667 h; Inert atmosphere;
2: chlorobenzene in tetrahydrofuran; m-xylene
T=150°C; 1 h; Inert atmosphereMicrowave irradiation;
参考文献
Huang, Wei-Sheng; Xu, Rongsong; Dodd, Rory; Shakespeare, William C.
Tetrahedron Letters, 2014 , vol. 55, # 2 p. 441 - 444
反应条件
potassium carbonate in acetone
20 h; Heating;
参考文献
Deshmukh; Jagtap; Mulik
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2007 , vol. 46, # 5 p. 852 - 859
反应条件
potassium hydroxide in acetone
参考文献
Worley,J.W. et al.
Journal of Organic Chemistry, 1975 , vol. 40, p. 1731 - 1734
参考文献
Carbipem
Patent: US4755509 A1, 1988 ;
