1: MeMgI / diethyl ether; tetrahydrofuran 2: (i) MeLi, THF, (ii) /BRN= 1098260/ 3: (i) CrO3, H2SO4, acetone, (ii) Et3N, CH2Cl2 View Scheme

magnesium Multistep reaction;

1: 2) satd.NH4Cl / 1) Et2O, -20 deg C 2: 1) O3 2) Et2NH / 2) CH2Cl2, Δ View Scheme

(i) CrO3, H2SO4, acetone, (ii) Et3N, CH2Cl2; Multistep reaction;

1: (i) MeLi, THF, (ii) /BRN= 1098260/ 2: (i) CrO3, H2SO4, acetone, (ii) Et3N, CH2Cl2 View Scheme

1: With (S)-p-Tol-BINAP; copper(l) chloride; sodium t-butanolate; polymethylhydrosiloxane in toluene T=0°C; 12 h; 2: With tetrabutyl ammonium fluoride; water in tetrahydrofuran; diethyl ether; toluene 1 h; 3: With E. coli expressing cyclohexanone monooxygenase; LB-Ampicillin medium; isopropyl 1-thio-β-D-galactopyranoside; D-glucose in glycerol T=30°C; Baeyer-Villiger oxidation; Title compound not separated from byproducts;