3,4-二溴噻吩[2,3-b]噻吩合成路线 （共 3 条）
反应条件
zinc in acetic acid
2 h; Heating / reflux;
参考文献
MERCK PATENT GMBH
Patent: WO2006/21277 A1, 2006 ;
Location in patent: Page/Page column 30-31 ;
反应条件
1: 85 percent / Br2 / CS2 / 54 h / Heating
2: 71 percent / Zn, AcOH / 3 h / Heating
View Scheme
参考文献
Otsubo, Tetsuo; Kono, Yasuhiro; Hozo, Norio; Miyamoto, Hisakazu; Aso, Yoshio; et al.
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 7 p. 2033 - 2041
反应条件
1: 1.) t-BuOK, n-BuLi, 2.) t-BuOH, HMPA / 1.) THF, hexane, from -100 to -30 deg C, 2 h, 2.) THF, hexane, a) -30 deg C, 3 h, b) RT, overnight
2: 85 percent / Br2 / CS2 / 54 h / Heating
3: 71 percent / Zn, AcOH / 3 h / Heating
View Scheme
参考文献
Otsubo, Tetsuo; Kono, Yasuhiro; Hozo, Norio; Miyamoto, Hisakazu; Aso, Yoshio; et al.
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 7 p. 2033 - 2041
