反应条件
1.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 2.5 h / 20 - 100 °C
2.1: trimethylamine / dichloromethane / 2 h / 0 °C
3.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.5 h
3.2: 120 °C
View Scheme
参考文献
Wang, Min; Gao, Mingzhang; Steele, Brandon L.; Glick-Wilson, Barbara E.; Brown-Proctor, Clive; Shekhar, Anantha; Hutchins, Gary D.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 14 p. 4713 - 4718