6-氯烟酸合成路线

参考文献

Helsinn Healthcare SA; Fadini, Luca; Manini, Peter; Pietra, Claudio; Giuliano, Claudio; Lovati, Emanuela; Cannella, Roberta; Venturini, Alessio; Stella, Valentino J.
Patent: US8426450 B1, 2013 ;

5326-23-86-氯烟酸

171178-46-45-Boc-氨基-2-氯吡啶-4-羧酸

参考文献

Cockerill, Stuart; Stubberfield, Colin; Stables, Jeremy; Carter, Malcolm; Guntrip, Stephen; Smith, Kathryn; McKeown, Steve; Shaw, Robert; Topley, Peter; Thomsen, Lindy; Affleck, Karen; Jowett, Amanda; Hayes, David; Willson, Malcolm; Woollard, Patrick; Spalding, David
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 11 p. 1401 - 1405

5326-23-86-氯烟酸+

75-65-0叔丁醇

171178-45-35-(N-叔丁氧羰基氨基)-2-氯吡啶

参考文献

Cockerill, Stuart; Stubberfield, Colin; Stables, Jeremy; Carter, Malcolm; Guntrip, Stephen; Smith, Kathryn; McKeown, Steve; Shaw, Robert; Topley, Peter; Thomsen, Lindy; Affleck, Karen; Jowett, Amanda; Hayes, David; Willson, Malcolm; Woollard, Patrick; Spalding, David
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 11 p. 1401 - 1405

5326-23-86-氯烟酸

101990-45-82-溴-5-(溴甲基)吡啶

参考文献

Tietze, Lutz F.; Nordmann, Gero
Synlett, 1999 , # 3 p. 342 - 344

5326-23-86-氯烟酸

115309-57-46-氯烟酸叔丁酯

参考文献

Zhang, Huiping; Watterson, Scott H.; Xiao, Zili; Dhar, T. G. Murali; Balasubramanian, Balu; Barrish, Joel C.; Chen, Bang-Chi
Organic Process Research and Development, 2010 , vol. 14, # 4 p. 936 - 938

5326-23-86-氯烟酸+

24424-99-5二碳酸二叔丁酯

115309-57-46-氯烟酸叔丁酯

参考文献

Wright, Stephen W.
Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 2 p. 442 - 445

5326-23-86-氯烟酸+

36805-97-7N,N-二甲基甲酰胺二叔丁基缩醛

115309-57-46-氯烟酸叔丁酯

参考文献

Hoffmann-Emery, Fabienne; Hilpert, Hans; Scalone, Michelangelo; Waldmeier, Pius
Journal of Organic Chemistry, 2006 , vol. 71, # 5 p. 2000 - 2008

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BRISTOL-MYERS SQUIBB COMPANY
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5326-23-86-氯烟酸+

67098-46-8

115309-57-46-氯烟酸叔丁酯

参考文献

Tanaka, Taisaku; Sugawara, Hajime; Maruoka, Hiroshi; Imajo, Seiichi; Muto, Tsuyoshi
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 14 p. 4233 - 4249

5326-23-86-氯烟酸

159153-39-63-(6-氯-3-吡啶)-丙烯酸乙酯

参考文献

Pandey, Ganesh; Bagul, Trusar D.; Sahoo, Akhil K.
Journal of Organic Chemistry, 1998 , vol. 63, # 3 p. 760 - 768