2-氨基-4-噻唑乙酸乙酯合成路线 （共 35 条）
反应条件
hydrogenchloride 3 h; Heating;
参考文献
Kumar; Green; Borysko; Wise; Wotring; Townsend
Journal of Medicinal Chemistry, 1993 , vol. 36, # 24 p. 3843 - 3848
反应条件
1: acetic acid; hydrogen bromide / 100 °C 2: ethanol / 1 h / 20 °C View Scheme
参考文献
ChemMedChem, , vol. 8, # 12 p. 1923 - 1929
反应条件
1: bromine / water / 0.5 h / 0 °C 2: acetic acid; hydrogen bromide / 100 °C 3: ethanol / 1 h / 20 °C View Scheme
参考文献
ChemMedChem, , vol. 8, # 12 p. 1923 - 1929
反应条件
in ethanol T=20°C; 1 h;
参考文献
ChemMedChem, , vol. 8, # 12 p. 1923 - 1929
反应条件
in ethanol 4 h; Heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 17, p. 1255 - 1257
参考文献
Justus Liebigs Annalen der Chemie, , vol. 261, p. 26
反应条件
sodium hydrogencarbonate in dichloromethane 16 h;
参考文献
Hardy, Kenneth D.; Harrington, Frank P.; Stachulski, Andrew V.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 6 p. 1227 - 1236
反应条件
tert.-butylnitrite; copper dichloride in tetrahydrofuran T=0°C; 3 h;
参考文献
EP1394154 A1, ;
Page 50, 51 ;
反应条件
1: 95 percent / acetic acid / 7 h / -5 - 20 °C 2: 97 percent / NaOH / 0.5 h / 20 °C View Scheme
参考文献
Bhattacharya, Santanu; Thomas, Mini
Tetrahedron Letters, 2000 , vol. 41, # 52 p. 10313 - 10317
反应条件
water; sodium hydroxide in ethanol 5 h; Reflux;
参考文献
Alexandru, Maria-Gabriela; Velickovic, Tanja Cirkovic; Jitaru, Ioana; Grguric-Sipka, Sanja; Draghici, Constantin
Central European Journal of Chemistry, 2010 , vol. 8, # 3 p. 639 - 645
