2-氨基-4-噻唑乙酸乙酯合成路线 （共 35 条）
反应条件
formic acid; acetic anhydride in di-isopropyl ether
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US4191762 A1, 1980 ;
反应条件
1 h; External cooling;
参考文献
Perrone; Alpegiani; Giudici; et al.
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 4 p. 1097 - 1111
反应条件
1: NaNO2; aqueous HNO3; H3PO4 / Behandeln der Reaktionsloesung mit Kupfer und wss. HBr 2: Raney nickel; ethanol; diethylamine / Hydrogenation 3: ethanolic KOH View Scheme
参考文献
Erlenmeyer; Morel
Helvetica Chimica Acta, 1945 , vol. 28, p. 362,363
反应条件
pyridine in benzene T=20°C; Acylation; 1 h;
参考文献
Altintas, Handan; Ates, Oeznur; Kocabalkanli, Ayse; Birteksoez, Seher; Oetuek, Guelten
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 3 p. 585 - 590
参考文献
SmithKline Beecham Corporation
Patent: US2002/91264 A1, 2002 ;
反应条件
in acetic acid T=-5 - 20°C; 7 h;
参考文献
Bhattacharya, Santanu; Thomas, Mini
Tetrahedron Letters, 2000 , vol. 41, # 52 p. 10313 - 10317
反应条件
triethylamine in anhydrous dichloroethane
参考文献
YAMANOUCHI PHARMACEUTICAL CO. LTD.
Patent: EP1225173 A1, 2002 ;
反应条件
1: pyridine / 90 °C 2: 0.1654 g / aq. NaOH / Heating View Scheme
参考文献
CIBA
Patent: DE752870 , 1940 ;
DRP/DRBP Org.Chem.
Full Text Show Details
Sprague; Lincoln; Ziegler
Journal of the American Chemical Society, 1946 , vol. 68, p. 268
反应条件
ammonia in methanol T=20°C; 144 h;
参考文献
Jaeschke, Georg; Spooren, Will; Vieira, Eric
Patent: US2007/197553 A1, 2007 ;
Location in patent: Page/Page column 37 ;
US 20070197553 A1
反应条件
1: NaNO2; aqueous HNO3; H3PO4 / Behandeln der Reaktionsloesung mit Kupfer und wss. HBr 2: Raney nickel; ethanol; diethylamine / Hydrogenation View Scheme
参考文献
Erlenmeyer; Morel
Helvetica Chimica Acta, 1945 , vol. 28, p. 362,363
