2-氨基-4-噻唑乙酸乙酯合成路线 (共 35 条)
反应条件
1: acetone
2: ethanol / Heating
3: aq. H2SO4
View Scheme
参考文献
Sawhney,S.N. et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1978 , vol. 16, p. 523 - 524
反应条件
1: 45.8 percent / ethanol / 8 h / Heating
2: 75.2 percent / NaOH / ethanol; H2O / 1 h / Heating
View Scheme
参考文献
Ding, Huaiwei; Chen, Zhe; Zhang, Cunlong; Xin, Tian; Wang, Yini; Song, Hongrui; Jiang, Yuyang; Chen, Yuzong; Xu, Yongnan; Tan, Chunyan
Molecules, 2012 , vol. 17, # 4 p. 4703 - 4716
反应条件
1: acetone
2: ethanol / Heating
3: aq. H2SO4
View Scheme
参考文献
Sawhney,S.N. et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1978 , vol. 16, p. 523 - 524
反应条件
1: acetone
2: ethanol / Heating
3: aq. H2SO4
View Scheme
参考文献
Ding, Huaiwei; Chen, Zhe; Zhang, Cunlong; Xin, Tian; Wang, Yini; Song, Hongrui; Jiang, Yuyang; Chen, Yuzong; Xu, Yongnan; Tan, Chunyan
Molecules, 2012 , vol. 17, # 4 p. 4703 - 4716
反应条件
N-chloro-succinimide; acetic acid
T=20°C; 3 h;
参考文献
NOVO NORDISK A/S
Patent: WO2006/58923 A1, 2006 ;
Location in patent: Page/Page column 52 ;
WO 2006/058923 A1
反应条件
tert.-butylnitrite; copper(ll) bromide in acetonitrile
T=-20 - 20°C; 2 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/114274 A1, 2006 ;
Location in patent: Page/Page column 25 ;
WO 2006/114274 A1
反应条件
in ethanol
8 h; Heating;
参考文献
Palagiano; Arenare; Luraschi; De Caprariis; Abignente; D'Amico; Filippelli; Rossi
European Journal of Medicinal Chemistry, 1995 , vol. 30, # 11 p. 901 - 909
反应条件
1: 79 percent / acetone / 24 h / 20 °C
2: 59 percent / 1M aq. NaHCO3 / CHCl3 / 0.33 h / 20 °C
3: ethanol / 1 h / Heating
View Scheme
参考文献
Sawhney,S.N. et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1978 , vol. 16, p. 523 - 524
反应条件
1: NaNO2; aqueous HNO3; H3PO4 / Behandeln der Reaktionsloesung mit Kupfer und wss. HBr
2: ethanolic KOH
View Scheme
参考文献
Erlenmeyer; Morel
Helvetica Chimica Acta, 1945 , vol. 28, p. 362,363
反应条件
pyridine; hydrogenchloride in dichloromethane; water; ethyl acetate
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US4254260 A1, 1981 ;