Boc-4-甲氧基-L-苯丙氨酸合成路线 （共 12 条）
反应条件
sodium hydroxide in 1,4-dioxane; water T=25°C; 6 h;
参考文献
Jones, David A.; Sawyer, Wilbur H.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 6 p. 696 - 698
反应条件
sodium hydroxide in 1,4-dioxane T=24°C; 2 h;
参考文献
Dourtoglou; Gross
Synthesis, 1984 , vol. NO. 7, p. 572 - 574
参考文献
Boger, Dale L.; Zhou, Jiacheng
Journal of the American Chemical Society, 1995 , vol. 117, # 28 p. 7364 - 7378
反应条件
hydrogenchloride; sodium hydroxide in tetrahydrofuran; water
参考文献
US5442044 A1, ;
US 5442044 A
反应条件
sodium hydroxide in 1,4-dioxane 48 h; Ambient temperature;
参考文献
Vince; Lee; Narang; Shirota
Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1511 - 1514
反应条件
sodium hydride in N,N-dimethyl-formamide T=10°C; 3 h; var. halogen in alkylation reagent, var. time; Product distribution;
参考文献
Mendelson, Wilford L.; Tickner, Ann M.; Lantos, Ivan
Journal of Organic Chemistry, 1983 , vol. 48, # 22 p. 4127 - 4129
反应条件
1: 1.) K2CO3 / 1.) H2O, 10 min, 2.) tert-butyl alcohol, ether, 25 min 2: K2CO3, 18-crown-6 / benzene / 1.5 h / Heating 3: NaOH / methanol; H2O / 0.5 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 9 p. 1944 - 1946
反应条件
1: K2CO3, 18-crown-6 / benzene / 1.5 h / Heating 2: NaOH / methanol; H2O / 0.5 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 9 p. 1944 - 1946
反应条件
1: 1.) K2CO3 / 1.) H2O, 10 min, 2.) tert-butyl alcohol, ether, 25 min 2: K2CO3, 18-crown-6 / benzene / 1.5 h / Heating 3: NaOH / methanol; H2O / 0.5 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 9 p. 1944 - 1946
参考文献
Tetrahedron, , vol. 49, # 17 p. 3521 - 3532
