[(2-茚满甲酰基)甲基]膦酸二甲酯合成路线 （共 8 条）
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran
T=-5 - 0°C; Inert atmosphere;
2: With hydrogenchloride in tetrahydrofuran; water
pH=ca. 4;
参考文献
Maloney, Kevin M.; Chung, John Y. L.
Journal of Organic Chemistry, 2009 , vol. 74, # 19 p. 7574 - 7576
反应条件
1: KOH / H2O / 16 h / Heating
2: 0.33 h / 200 °C
3: 94 percent / conc. H2SO4 / 1 h / Heating
4: 1) n-BuLi / 1) THF, hexane, -78 deg C, 30 min, 2) THF, 1.5 h
View Scheme
参考文献
Tomiyama; Wakabayashi; Yokota
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1988 - 1996
反应条件
1: Na / ethanol; diethyl ether / 5 h / Heating
2: KOH / H2O / 16 h / Heating
3: 0.33 h / 200 °C
4: 94 percent / conc. H2SO4 / 1 h / Heating
5: 1) n-BuLi / 1) THF, hexane, -78 deg C, 30 min, 2) THF, 1.5 h
View Scheme
参考文献
Tomiyama; Wakabayashi; Yokota
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1988 - 1996
反应条件
1: 100 percent / p-toluenesulfonic acid hydrate / benzene / 3.5 h / Heating
2: 48 percent / 190 - 200 °C
3: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 5 min, 2.) THF, hexane, -78 deg C, 1.0 h
View Scheme
参考文献
Schaaf; Johnson; Constantine; Bindra; Hess; Elger
Journal of Medicinal Chemistry, 1983 , vol. 26, # 3 p. 328 - 334
反应条件
1: 94 percent / conc. H2SO4 / 1 h / Heating
2: 1) n-BuLi / 1) THF, hexane, -78 deg C, 30 min, 2) THF, 1.5 h
View Scheme
参考文献
Tomiyama; Wakabayashi; Yokota
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1988 - 1996
反应条件
1: 0.33 h / 200 °C
2: 94 percent / conc. H2SO4 / 1 h / Heating
3: 1) n-BuLi / 1) THF, hexane, -78 deg C, 30 min, 2) THF, 1.5 h
View Scheme
参考文献
Tomiyama; Wakabayashi; Yokota
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1988 - 1996
反应条件
1: 48 percent / 190 - 200 °C
2: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 5 min, 2.) THF, hexane, -78 deg C, 1.0 h
View Scheme
参考文献
Schaaf; Johnson; Constantine; Bindra; Hess; Elger
Journal of Medicinal Chemistry, 1983 , vol. 26, # 3 p. 328 - 334
反应条件
n-butyllithium
1.) THF, hexane, -78 deg C, 5 min, 2.) THF, hexane, -78 deg C, 1.0 h; Yield given. Multistep reaction;
参考文献
Schaaf; Johnson; Constantine; Bindra; Hess; Elger
Journal of Medicinal Chemistry, 1983 , vol. 26, # 3 p. 328 - 334
