4-氯-6-甲基烟酸甲酯合成路线 （共 11 条）
反应条件
1: 2-chloro-6-methyl-3-pyridine carboxylic acid With oxalyl dichloride in dichloromethane 0.5 h; 2: methanol T=0 - 20°C;
参考文献
Le Hir de Fallois, Loic Patrick; Lee, Hyoung Ik; Wilkinson, Douglas Edward; Beck, Brent Christopher
Patent: US2011/152312 A1, 2011 ;
Location in patent: Page/Page column 35 ;
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) 18 h;
参考文献
Lee, Jinbo; Kirincich, Steve J.; Smith, Michael J.; Wilson, Douglas P.; Follows, Bruce C.; Wan, Zhao-Kui; Joseph-McCarthy, Diane M.; Erbe, David V.; Zhang, Yan-Ling; Xu, Weixin; Tam, Steve Y.
Patent: US2005/203081 A1, 2005 ;
Location in patent: Page/Page column 12; 30 ;
US 20050203081 A1
反应条件
in dichloromethane T=0°C;
参考文献
MERIAL LIMITED; LE HIR DE FALOIS, Loic, Patrick; LEE, Hyoung, Lk; WILKINSON, Douglas, Edward; BECK, Brent, Christopher
Patent: WO2011/75591 A1, 2011 ;
Location in patent: Page/Page column 84 ;
反应条件
methanol in dichloromethane T=20°C; 0.333333 h; Inert atmosphere;
参考文献
WO2010/122151 A1, ;
Page/Page column 52 ;
WO 2010/122151 A1
反应条件
in methanol; dichloromethane; chloroform; N,N-dimethyl-formamide
参考文献
Ashworth, Doreen; Pitt, Gary R W; Hudson, Peter; Yea, Christopher; Franklin, Richard J; Semple, Graeme; Jenkins, David Paul
Patent: US2004/38962 A1, 2004 ;
反应条件
1: POCl3 / 2 h / Heating 2: 4.56 g / 1.5 h / Heating View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 3, # 6 p. 996 - 1001
参考文献
Jonsson, Stefan; Arribas, Carlos Solano; Wendt, Ola F.; Siegel, Jay S.; Waernmark, Kenneth
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 6 p. 996 - 1001
反应条件
trimethylsilyl bromide T=160°C; 0.333333 h; Inert atmosphere;
参考文献
ALVARO, Giuseppe; Amantini, David; Castiglioni, Emiliano; Di Fabio, Romano; Pavone, Francesca
Patent: US2010/144760 A1, 2010 ;
Location in patent: Page/Page column 31 ;
US 20100144760 A1
反应条件
1: 80 percent / ethanol / Heating 2: 2.) Na, EtOH / 1,) Et2O, RT, 1 h, 2.) warming, 5 min View Scheme
参考文献
Santilli, Arthur A.; Scotese, Anthony C.; Bauer, Raymond F.; Bell, Stanley C.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 12 p. 2270 - 2277
参考文献
American Home Products Corporation
Patent: US4215123 A1, 1980 ;
