(2-氨基-5-碘苯基)甲醇合成路线 （共 8 条）
反应条件
diisobutylaluminium hydride in tetrahydrofuran; cyclohexane
T=-41 - 20°C; Inert atmosphere;
参考文献
Cronk, W. Cole; Mukhina, Olga A.; Kutateladze, Andrei G.
Journal of Organic Chemistry, 2014 , vol. 79, # 3 p. 1235 - 1246
反应条件
iodine cloride in acetic acid
T=23°C; 2 h;
参考文献
Steinhagen, Henning; Corey
Organic Letters, 1999 , vol. 1, # 5 p. 823 - 824
反应条件
lithium borohydride in methanol
T=0°C;
参考文献
Badarinarayana, Vivek; Lovely, Carl J.
Tetrahedron Letters, 2007 , vol. 48, # 14 p. 2607 - 2610
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=0 - 20°C;
参考文献
Sabbatini, Paola; Wellendorph, Petrine; Hog, Signe; Pedersen, Martin H. F.; Braeuner-Osborne, Hans; Martiny, Lars; Frolund, Bente; Clausen, Rasmus P.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 17 p. 6506 - 6510
反应条件
1.1: 90 percent / H2 / Pd/C / ethanol
2.1: n-C5H11ONO; CH2I2
3.1: TBAF / tetrahydrofuran
4.1: o-NO2C6H4SeCN; PBu3 / tetrahydrofuran
4.2: 85 percent / H2O2 / tetrahydrofuran
5.1: 15 percent / LiBH4 / methanol / 0 °C
View Scheme
参考文献
Badarinarayana, Vivek; Lovely, Carl J.
Tetrahedron Letters, 2007 , vol. 48, # 14 p. 2607 - 2610
反应条件
sodium tetrahydroborate; zinc(II) chloride in tetrahydrofuran
Reduction;
参考文献
Smith III, Amos B.; Ducry, Laurent; Corbett, R. Michael; Hirschmann, Ralph
Organic Letters, 2000 , vol. 2, # 24 p. 3887 - 3890
反应条件
1.1: o-NO2C6H4SeCN; PBu3 / tetrahydrofuran
1.2: 85 percent / H2O2 / tetrahydrofuran
2.1: 15 percent / LiBH4 / methanol / 0 °C
View Scheme
参考文献
Badarinarayana, Vivek; Lovely, Carl J.
Tetrahedron Letters, 2007 , vol. 48, # 14 p. 2607 - 2610
反应条件
1.1: n-C5H11ONO; CH2I2
2.1: TBAF / tetrahydrofuran
3.1: o-NO2C6H4SeCN; PBu3 / tetrahydrofuran
3.2: 85 percent / H2O2 / tetrahydrofuran
4.1: 15 percent / LiBH4 / methanol / 0 °C
View Scheme
参考文献
Badarinarayana, Vivek; Lovely, Carl J.
Tetrahedron Letters, 2007 , vol. 48, # 14 p. 2607 - 2610
