反应条件
1: hex-5-ynoic acid With n-butyllithium in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide
T=-40°C; Metallation; 1 h;
2: formaldehyd in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide
T=20°C; Addition; 2 h;
参考文献
Kambe, Tohru; Maruyama, Toru; Naganawa, Atsushi; Asada, Masaki; Seki, Akiteru; Maruyama, Takayuki; Nakai, Hisao; Toda, Masaaki
Chemical and Pharmaceutical Bulletin, 2011 , vol. 59, # 12 p. 1494 - 1508