4-氨基-3-氯苯磺酰胺合成路线 （共 11 条）
反应条件
hydrogenchloride 0.75 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 11 p. 2187 - 2196
反应条件
1: NH3 / tetrahydrofuran 2: aq. HCl / ethanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 17 p. 4444 - 4449
反应条件
1: chlorosulfonic acid / 3.5 h / 70 - 80 °C 2: aq. NH4OH / 0.5 h / 70 °C 3: aq. HCl / 0.75 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 11 p. 2187 - 2196
反应条件
1: 100 percent / 0.5 h / Heating 2: chlorosulfonic acid / 3.5 h / 70 - 80 °C 3: aq. NH4OH / 0.5 h / 70 °C 4: aq. HCl / 0.75 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 11 p. 2187 - 2196
反应条件
trichloroisocyanuric acid in perchloric acid; acetic acid T=34.9°C; other temp., ΔH(excit.), ΔS(excit.), Ea(activ.); KineticsThermodynamic dataMechanism;
参考文献
Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical & Analytical, , vol. 27, # 12 p. 1028 - 1030
反应条件
sodium hydroxide; iodine; potassium iodide T=0 - 4°C;
参考文献
Supuran, Claudiu T; Briganti, Fabrizio; Tilli, Silvia; Chegwidden; Scozzafava, Andrea
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 3 p. 703 - 714
反应条件
sodium hydroxide; sodium hypochlorite T=25 - 30°C;
参考文献
Supuran, Claudiu T; Briganti, Fabrizio; Tilli, Silvia; Chegwidden; Scozzafava, Andrea
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 3 p. 703 - 714
参考文献
Ilies, Marc A.; Vullo, Daniela; Pastorek, Jaromir; Scozzafava, Andrea; Ilies, Monica; Caproiu, Miron T.; Pastorekova, Silvia; Supuran, Claudiu T.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2187 - 2196
反应条件
sodium hydroxide; sodium hypochlorite
T=25 - 30°C; thiocarbamylation;
参考文献
Scozzafava, Andrea; Supuran, Claudiu T.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 10 p. 1117 - 1120
反应条件
triethylamine in acetonitrile
T=0 - 5°C;
参考文献
Guezel, Oezlen; Innocenti, Alessio; Scozzafava, Andrea; Salman, Aydin; Supuran, Claudiu T.
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 14 p. 4894 - 4899
