N-(2-氯苯基)乙酰胺合成路线 （共 129 条）
反应条件
1: K2CO3, CuI / 17 h / Heating 2: KOH / ethanol / 2 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , # 4 p. 619 - 624
反应条件
copper; potassium carbonate
参考文献
Journal of the Indian Chemical Society, , vol. 34, p. 413
反应条件
2: 81 percent / LDA / tetrahydrofuran / 0.5 h / Ambient temperature; Irradiation View Scheme
参考文献
Goehring, R. Richard; Sachdeva, Yesh P.; Pisipati, Jyothi S.; Sleevi, Mark C.; Wolfe, James F.
Journal of the American Chemical Society, 1985 , vol. 107, # 2 p. 435 - 443
反应条件
lithium aluminium tetrahydride
参考文献
Zhu, Manghong; Zhang, Chen; Nwachukwu, Jerome C.; Srinivasan, Sathish; Cavett, Valerie; Zheng, Yangfan; Carlson, Kathryn E.; Dong, Chune; Katzenellenbogen, John A.; Nettles, Kendall W.; Zhou, Hai-Bing
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 43 p. 8692 - 8700
反应条件
chlorosulphuric acid
参考文献
Gupta; Phull, Manjinder Singh
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996 , vol. 35, # 9 p. 967 - 969
反应条件
1: chlorosulfonic acid / 3.5 h / 70 - 80 °C 2: aq. NH4OH / 0.5 h / 70 °C 3: aq. HCl / 0.75 h / Heating 4: aq. HCl; H2O2 / 1.08 h / 50 - 80 °C View Scheme
参考文献
Ilies, Marc A.; Vullo, Daniela; Pastorek, Jaromir; Scozzafava, Andrea; Ilies, Monica; Caproiu, Miron T.; Pastorekova, Silvia; Supuran, Claudiu T.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2187 - 2196
反应条件
1.1: 2,6-dimethylpyridine; trifluoromethylsulfonic anhydride / dichloromethane / 1 h / 0 - 20 °C / |Inert atmosphere
1.2: 20 °C / |Inert atmosphere
2.1: potassium hydroxide / dimethyl sulfoxide / 24 h / 120 °C / |Inert atmosphere
View Scheme
参考文献
Baars, Hannah; Beyer, Astrid; Kohlhepp, Stefanie V.; Bolm, Carsten
Organic Letters, 2014 , vol. 16, # 2 p. 536 - 539
反应条件
tetrabutylammomium bromide; potassium carbonate; [1-cyclohexyl-3-(di-pyridin-2-yl-methyl)-urea][PdCl2] in water
T=100°C; Suzuki-Miyaura coupling; 47 h;
参考文献
Najera, Carmen; Gil-Molto, Juan; Karlstroem, Sofia
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1798 - 1811
反应条件
2: 57 percent / KNH2 / benzene; liquid ammonia / 0.5 h / Irradiation
View Scheme
参考文献
Goehring, R. Richard; Sachdeva, Yesh P.; Pisipati, Jyothi S.; Sleevi, Mark C.; Wolfe, James F.
Journal of the American Chemical Society, 1985 , vol. 107, # 2 p. 435 - 443
反应条件
nitric acid
T=-10°C;
参考文献
Lobry de Bruyn
Recueil des Travaux Chimiques des Pays-Bas, 1917 , vol. 36, p. 139
