N-(2-氯苯基)乙酰胺合成路线 （共 129 条）
反应条件
lithium diisopropyl amide in tetrahydrofuran 3 h; Ambient temperatureIrradiation;
参考文献
Goehring, R. Richard; Sachdeva, Yesh P.; Pisipati, Jyothi S.; Sleevi, Mark C.; Wolfe, James F.
Journal of the American Chemical Society, 1985 , vol. 107, # 2 p. 435 - 443
反应条件
1: N-(2-chlorophenyl)-acetamide With dichloro bis(acetonitrile) palladium(II); Cy-DHTP*HBF4; lithium tert-butylate in toluene T=20°C; 0.666667 h; Inert atmosphere; 2: phenylacetylene in toluene Sonogashira Cross-Coupling; 3 h; Inert atmosphereReflux; 3: With water in toluene 3 h; Inert atmosphereReflux;
参考文献
Organic Letters, , vol. 16, # 9 p. 2386 - 2389
反应条件
1: N-(2-chlorophenyl)-acetamide With dichloro bis(acetonitrile) palladium(II); Cy-DHTP*HBF4; lithium tert-butylate in toluene T=20°C; 0.666667 h; Inert atmosphere; 2: phenylacetylene in toluene Sonogashira Cross-Coupling; 3 h; Inert atmosphereReflux; 3: With water in toluene 3 h; Inert atmosphereReflux;
参考文献
Yamaguchi, Miyuki; Manabe, Kei
Organic Letters, 2014 , vol. 16, # 9 p. 2386 - 2389
反应条件
KOCl; potassium dicarbonate
参考文献
Chattaway; Orton
Journal of the Chemical Society, 1900 , vol. 77, p. 791
反应条件
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / |Inert atmosphere 1.2: 0 - 20 °C / |Inert atmosphere 2.1: hydrogenchloride / water; ethylene glycol / 24 h / |Reflux; |Inert atmosphere View Scheme
参考文献
Zhu, Manghong; Zhang, Chen; Nwachukwu, Jerome C.; Srinivasan, Sathish; Cavett, Valerie; Zheng, Yangfan; Carlson, Kathryn E.; Dong, Chune; Katzenellenbogen, John A.; Nettles, Kendall W.; Zhou, Hai-Bing
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 43 p. 8692 - 8700
参考文献
Franzen; Engel
Journal fuer Praktische Chemie (Leipzig), 1921 , vol. <2>102, p. 184
反应条件
hydrogenchloride; 3-chloro-benzenecarboperoxoic acid T=20°C; 0.5 h;
参考文献
Chung; Kim; Ryu
Synthetic Communications, 1991 , vol. 21, # 18-19 p. 1917 - 1922
反应条件
aluminium trichloride Fries rearrangement; 0.0583333 h; microwave irradiation;
参考文献
Easwaramurthy; Ravikumar; Lakshmanan; Raju
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 3 p. 635 - 637
反应条件
1: chlorosulfonic acid / 3.5 h / 70 - 80 °C 2: aq. NH4OH / 0.5 h / 70 °C 3: aq. HCl / 0.75 h / Heating View Scheme
参考文献
Ilies, Marc A.; Vullo, Daniela; Pastorek, Jaromir; Scozzafava, Andrea; Ilies, Monica; Caproiu, Miron T.; Pastorekova, Silvia; Supuran, Claudiu T.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2187 - 2196
反应条件
sulfuric acid; nitric acid man waescht den Niederschlag mit Wasser aus und destilliert mit Natronlauge; die ueberdestillierten Basen trennt man durch Krystallisation aus Ligroin;
参考文献
Beilstein; Kurbatow
Justus Liebigs Annalen der Chemie, 1876 , vol. 182, p. 108
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1877 , vol. 9, p. 110
