1-苯基戊烷-1,3-二酮合成路线 （共 36 条）
参考文献
Bredereck et al.
Angewandte Chemie, 1956 , vol. 68, p. 151
Chemische Berichte, 1957 , vol. 90, p. 942,950
反应条件
sodium nitrite in water; acetic acid
T=15 - 20°C; 4 h;
参考文献
AVENTIS PHARMACEUTICALS INC.
Patent: WO2005/12301 A1, 2005 ;
Location in patent: Page/Page column 47 ;
WO 2005/012301 A1
反应条件
1: 70 percent / conc. HCl / ethanol / 48 h / Heating
2: 85 percent / phosphoryl chloride / 3 h / Heating
View Scheme
参考文献
Sakamoto, Takao; Sakasai, Takeji; Yoshizawa, Hiroshi; Tanji, Ken-Ichi; Nishimura, Sumiko; Yamanaka, Hiroshi
Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 12 p. 4554 - 4560
反应条件
1: 70 percent / conc. HCl / ethanol / 48 h / Heating
2: 85 percent / phosphoryl chloride / 3 h / Heating
3: 96 percent / hydrogen/conc. ammonia / 5percent palladium charcoal / methanol
4: 79 percent / propyl nitrite, HCl / ethanol / 2 h / Ambient temperature
View Scheme
参考文献
Sakamoto, Takao; Sakasai, Takeji; Yoshizawa, Hiroshi; Tanji, Ken-Ichi; Nishimura, Sumiko; Yamanaka, Hiroshi
Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 12 p. 4554 - 4560
反应条件
hydrogenchloride in ethanol
48 h; Heating;
参考文献
Sakamoto, Takao; Sakasai, Takeji; Yoshizawa, Hiroshi; Tanji, Ken-Ichi; Nishimura, Sumiko; Yamanaka, Hiroshi
Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 12 p. 4554 - 4560
反应条件
1: 70 percent / conc. HCl / ethanol / 48 h / Heating
2: 85 percent / phosphoryl chloride / 3 h / Heating
3: 96 percent / hydrogen/conc. ammonia / 5percent palladium charcoal / methanol
4: 79 percent / propyl nitrite, HCl / ethanol / 2 h / Ambient temperature
5: 81 percent / pyruvic acid, conc. HCl / aq. ethanol / 6 h / Heating
View Scheme
参考文献
Sakamoto, Takao; Sakasai, Takeji; Yoshizawa, Hiroshi; Tanji, Ken-Ichi; Nishimura, Sumiko; Yamanaka, Hiroshi
Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 12 p. 4554 - 4560
