6-氨基-3-甲基-1,4-二苯基-1,4-二氢-吡喃o[2,3-c]吡唑-5-甲腈合成路线 （共 12 条）
反应条件
N-benzyl-N,N,N-triethylammonium chloride in water
T=90°C; 6 h;
参考文献
Guo, Shao-Bo; Wang, Shu-Xiang; Li, Ji-Tai
Synthetic Communications, 2007 , vol. 37, # 13 p. 2111 - 2120
反应条件
magnesium oxide in acetonitrile
Michael addition; 0.333333 h; Reflux;
参考文献
Sheibani, Hassan; Babaie, Maryam
Synthetic Communications, 2010 , vol. 40, # 2 p. 257 - 265
反应条件
N-hexadecyl-N,N,N-trimethylammonium bromide in water
T=90°C; 4 h; Green chemistry;
参考文献
Wu, Mingshu; Feng, Qinqin; Wan, Dehui; Ma, Jinya
Synthetic Communications, 2013 , vol. 43, # 12 p. 1721 - 1726
反应条件
morpholine in methanol
Heating;
参考文献
Sharanin, Yu. A.; Promonenkov, V. K.; Sharanina, L. G.
Journal of Organic Chemistry USSR (English Translation), 1982 , vol. 18, p. 544 - 548
Zhurnal Organicheskoi Khimii, 1982 , vol. 18, # 3 p. 625 - 629
反应条件
magnesium oxide in acetonitrile
Michael addition; 0.2 h; Reflux;
参考文献
Sheibani, Hassan; Babaie, Maryam
Synthetic Communications, 2010 , vol. 40, # 2 p. 257 - 265
反应条件
triethylamine in benzene
4.5 h;
参考文献
Tacconi, G.; Gatti, G.; Desimoni G.; Messori, V.
Journal fuer Praktische Chemie (Leipzig), 1980 , vol. 322, # 5 p. 831 - 834
反应条件
1: 95 percent / methanol / 30 - 35 °C
2: 93 percent / morpholine / methanol / Heating
View Scheme
参考文献
Sharanin, Yu. A.; Promonenkov, V. K.; Sharanina, L. G.
Journal of Organic Chemistry USSR (English Translation), 1982 , vol. 18, p. 544 - 548
Zhurnal Organicheskoi Khimii, 1982 , vol. 18, # 3 p. 625 - 629
反应条件
1: 95 percent / methanol / 30 - 35 °C
2: 93 percent / morpholine / methanol / Heating
View Scheme
参考文献
Sharanin, Yu. A.; Promonenkov, V. K.; Sharanina, L. G.
Journal of Organic Chemistry USSR (English Translation), 1982 , vol. 18, p. 544 - 548
Zhurnal Organicheskoi Khimii, 1982 , vol. 18, # 3 p. 625 - 629
反应条件
1: ethanol / 3 h / 0 - 60 °C
2: sodium sulfate / dichloromethane / 25 h / 20 °C
View Scheme
参考文献
THE REGENTS OF THE UNIVERSITY OF COLORADO; THE UNIVERSITY OF VIRGINIA PATENT FOUNDATION; INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION; THEODORESCU, Dan; WEMPE, Michael, Fitzpatrick; ROSS, David; MEROUEH, Samy; SCHWARTZ, Martin, A.; REIGAN, Phillip
Patent: WO2013/96820 A1, 2013 ;
反应条件
1: ethanol; water / 20 °C
2: ethanol; water / 2.5 h / 100 °C
View Scheme
参考文献
Mandha, Santhosh Reddy; Siliveri, Sravanthi; Alla, Manjula; Bommena, Vittal Rao; Bommineni, Madhava Reddy; Balasubramanian, Sridhar
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 16 p. 5272 - 5278
