1,2,3,5-四甲氧基苯合成路线 （共 92 条）
反应条件
1: (i) nBuLi, hexane, THF, (ii) /BRN= 506159/
2: (i) nBuLi, hexane, THF, (ii) /BRN= 506159/
3: (i) BBr3, CH2Cl2, (ii) aq. H2SO4, Fe2(SO4)3, EtOH
View Scheme
参考文献
Schill,G. et al.
Chemische Berichte, 1975 , vol. 108, p. 1570 - 1579
反应条件
1: AlCl3; diethyl ether
2: sodium benzoate / 180 °C
3: aqueous hydriodic acid / 130 °C
View Scheme
参考文献
Hattori
Acta Phytochimica, 1930 , vol. 5, p. 103,110
Chem. Zentralbl., 1931 , vol. 102, # I p. 1760
反应条件
nitric acid in acetic anhydride
参考文献
Collins,B.A. et al.
Journal of the Chemical Society, Chemical Communications, 1972 , p. 1216
反应条件
aluminium trichloride; benzene
参考文献
Ponniah; Seshadri
Proceedings - Indian Academy of Sciences, Section A, 1954 , # 39 p. 45,50
反应条件
1: 1,2,4,5,6-tetramethoxybenzene With n-butyllithium in tetrahydrofuran
T=-78°C; Inert atmosphere;
2: carbon dioxide in tetrahydrofuran
Inert atmosphere;
参考文献
Caldwell, Stuart T.; McPhail, Donald B.; Duthie, Garry G.; Hartley, Richard C.
Canadian Journal of Chemistry, 2012 , vol. 90, # 1 p. 23 - 33
反应条件
1: aluminium chloride; carbon disulfide
2: ethanolic KOH-solution
View Scheme
参考文献
Bargellini; Madesani
Gazzetta Chimica Italiana, 1931 , vol. 61, p. 684,691
反应条件
1: 1.) aluminium chloride, 2.) 15percent hydrochloric acid / 1.) ether, 0 deg C, 3 h, 2.) water, 0 deg C
2: 1.) sodium, 2.) EtOH, concentrated HCl / 1.) room temperature, 2.) heating, 15-20 min
View Scheme
参考文献
Chatterjea, J. N.; Shaw, S. C.; Fatma, A.
Journal of the Indian Chemical Society, 1985 , vol. 62, p. 990 - 992
反应条件
1: AlCl3; diethyl ether
2: aq. NaOH solution; aqueous .K2S2O8 / und Erhitzen des Reaktionsprodukts mit wss.HCl
View Scheme
参考文献
Baker
Journal of the Chemical Society, 1941 , p. 662,669
反应条件
1: aluminum chloride / diethyl ether / 0.5 h / 0 °C
2: aluminum chloride / acetonitrile / 2 h / 50 °C
View Scheme
参考文献
Horie, Tokunaru; Tominaga, Hideaki; Kawamura, Yasuhiko; Hada, Takahiko; Ueda, Natsuo; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2169 - 2176
反应条件
aluminium trichloride in diethyl ether
T=22°C; 20 h; Yield given. Yields of byproduct given;
参考文献
Rizzi, George P.
Synthetic Communications, 1983 , vol. 13, # 14 p. 1173 - 1180
